Cargando…

Prevalence of Phosphatidylinositol-3-Kinase (PI3K) Pathway Alterations and Co-alteration of Other Molecular Markers in Breast Cancer

Background: PI3K/AKT signaling pathway is activated in breast cancer and associated with cell survival. We explored the prevalence of PI3K pathway alterations and co-expression with other markers in breast cancer subtypes. Methods: Samples of non-matched primary and metastatic breast cancer submitte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khoury, Katia, Tan, Antoinette R., Elliott, Andrew, Xiu, Joanne, Gatalica, Zoran, Heeke, Arielle L., Isaacs, Claudine, Pohlmann, Paula R., Schwartzberg, Lee S., Simon, Michael, Korn, W. Michael, Swain, Sandra M., Lynce, Filipa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489343/ https://www.ncbi.nlm.nih.gov/pubmed/32983983 http://dx.doi.org/10.3389/fonc.2020.01475

Ejemplares similares

Bone-Modifying Agents in Early-Stage and Advanced Breast Cancer
por: Heeke, Arielle, et al.
Publicado: (2018)

Checkpoint inhibitor therapy for metastatic triple-negative breast cancer
por: Heeke, Arielle L., et al.
Publicado: (2021)

PALINA: A phase II safety study of palbociclib in combination with letrozole or fulvestrant in African American women with hormone receptor positive HER2 negative advanced breast cancer
por: Lynce, Filipa, et al.
Publicado: (2018)

HALT-D: a randomized open-label phase II study of crofelemer for the prevention of chemotherapy-induced diarrhea in patients with HER2-positive breast cancer receiving trastuzumab, pertuzumab, and a taxane
por: Pohlmann, Paula R., et al.
Publicado: (2022)

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
por: Marty, Bérengère, et al.
Publicado: (2008)

Phosphatidylinositol 3‐kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities
por: Millis, Sherri Z., et al.
Publicado: (2018)

NUTM1-Rearranged Neoplasms—A Heterogeneous Group of Primitive Tumors with Expanding Spectrum of Histology and Molecular Alterations—An Updated Review
por: Luo, Wenyi, et al.
Publicado: (2021)

Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation
por: Kent, Lindsey N, et al.
Publicado: (2010)

Phosphatidylinositol 3-Kinase Plays a Vital Role in Regulation of Rice Seed Vigor via Altering NADPH Oxidase Activity
por: Liu, Jian, et al.
Publicado: (2012)

Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3‐Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations
por: Bardia, Aditya, et al.
Publicado: (2019)

Differences in Uptake of Risk Reduction Strategies Among Underserved Populations
por: Lynce, Filipa, et al.
Publicado: (2015)

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate
por: Pokorny, Daniel, et al.
Publicado: (2021)

Therapeutic approach guided by genetic alteration: Use of MTOR inhibitor in renal medullary carcinoma with loss of PTEN expression
por: Lipkin, Jacob S, et al.
Publicado: (2015)

Phosphatidylinositol 3‐Kinase δ Deficiency Protects From Antimyeloperoxidase Vasculitis
por: Flórez‐Barrós, Fernanda, et al.
Publicado: (2022)

Multiple Phosphatidylinositol 3-Kinases Regulate Vaccinia Virus Morphogenesis
por: McNulty, Shannon, et al.
Publicado: (2010)

Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics
por: Akinleye, Akintunde, et al.
Publicado: (2013)

Phosphatidylinositol 3-Monophosphate Is Involved in Toxoplasma Apicoplast Biogenesis
por: Tawk, Lina, et al.
Publicado: (2011)

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
por: Baskaran, Sulochanadevi, et al.
Publicado: (2014)

Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome
por: Cohen, Jeffrey I.
Publicado: (2018)

Management of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia
por: Goncalves, Marcus D., et al.
Publicado: (2022)

Video intervention increases participation of black breast cancer patients in therapeutic trials
por: Robinson, Brandi N., et al.
Publicado: (2017)

High microsatellite instability (MSI-H) colorectal carcinoma: a brief review of predictive biomarkers in the era of personalized medicine
por: Gatalica, Zoran, et al.
Publicado: (2016)

Profile of Margetuximab: Evidence to Date in the Targeted Treatment of Metastatic HER2-positive Breast Cancer
por: Schlam, Ilana, et al.
Publicado: (2022)

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α
por: Lo, Wen-Ting, et al.
Publicado: (2022)

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer
por: Knowles, Margaret A., et al.
Publicado: (2009)

Trop-2 protein as a therapeutic target: A focused review on Trop-2-based antibody-drug conjugates and their predictive biomarkers
por: Vranic, Semir, et al.
Publicado: (2022)

PD-L1 testing by immunohistochemistry in immuno-oncology
por: Vranic, Semir, et al.
Publicado: (2023)

Phosphatidylinositol 3-Kinase Is a Negative Regulator of Cellular Differentiation
por: Ptasznik, Andrzej, et al.
Publicado: (1997)

The phosphatidylinositol-3 kinase/mTOR pathway: new agents
por: Arteaga, CL
Publicado: (2011)

Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment
por: Brana, Irene, et al.
Publicado: (2012)

Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy
por: Zhao, Wennan, et al.
Publicado: (2017)

Phosphatidylinositol 3‐monophosphate: A novel actor in thrombopoiesis and thrombosis
por: Valet, Colin, et al.
Publicado: (2020)

Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking
por: Yoshioka, Kazuaki
Publicado: (2021)

Endocrine therapy initiation, discontinuation and adherence and breast imaging among 21-gene recurrence score assay-eligible women under age 65
por: O’Neill, Suzanne C., et al.
Publicado: (2017)

Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice
por: Huang, Ping, et al.
Publicado: (2011)

Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity
por: Ruch, Travis R., et al.
Publicado: (2017)

The interdependent transport of yeast vacuole Ca(2+) and H(+) and the role of phosphatidylinositol 3,5-bisphosphate
por: Zhang, Chi, et al.
Publicado: (2022)

A novel phosphatidylinositol(3,4,5)P(3) pathway in fission yeast
por: Mitra, Prasenjit, et al.
Publicado: (2004)

The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer
por: Chu, Chien-An, et al.
Publicado: (2021)

Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals
por: Nicholson-Fish, Jessica C., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_072a0tqp296idjqanqqjnqcbnl