Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice

The cellular prion protein, PrP(C), is a glycosylphosphatidylinositol anchored-membrane glycoprotein expressed most abundantly in neuronal and to a lesser extent in non-neuronal cells. Its conformational conversion into the amyloidogenic isoform in neurons is a key pathogenic event in prion diseases...

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Detalles Bibliográficos
Autores principales: Chida, Junji, Hara, Hideyuki, Uchiyama, Keiji, Takahashi, Etsuhisa, Miyata, Hironori, Kosako, Hidetaka, Tomioka, Yukiko, Ito, Toshihiro, Horiuchi, Hiroyuki, Matsuda, Haruo, Kido, Hiroshi, Sakaguchi, Suehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489546/
https://www.ncbi.nlm.nih.gov/pubmed/32845931
http://dx.doi.org/10.1371/journal.ppat.1008823

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