SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site. Both ACE2 and heparin can bind in...

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Detalles Bibliográficos
Autores principales: Clausen, Thomas Mandel, Sandoval, Daniel R., Spliid, Charlotte B., Pihl, Jessica, Perrett, Hailee R., Painter, Chelsea D., Narayanan, Anoop, Majowicz, Sydney A., Kwong, Elizabeth M., McVicar, Rachael N., Thacker, Bryan E., Glass, Charles A., Yang, Zhang, Torres, Jonathan L., Golden, Gregory J., Bartels, Phillip L., Porell, Ryan N., Garretson, Aaron F., Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake M., Caradonna, Timothy M., Kellman, Benjamin P., Martino, Cameron, Gordts, Philip L.S.M., Chanda, Sumit K., Schmidt, Aaron G., Godula, Kamil, Leibel, Sandra L., Jose, Joyce, Corbett, Kevin D., Ward, Andrew B., Carlin, Aaron F., Esko, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489987/
https://www.ncbi.nlm.nih.gov/pubmed/32970989
http://dx.doi.org/10.1016/j.cell.2020.09.033

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