Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these...

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Detalles Bibliográficos
Autores principales: Baran-Gale, Jeanette, Morgan, Michael D, Maio, Stefano, Dhalla, Fatima, Calvo-Asensio, Irene, Deadman, Mary E, Handel, Adam E, Maynard, Ashley, Chen, Steven, Green, Foad, Sit, Rene V, Neff, Norma F, Darmanis, Spyros, Tan, Weilun, May, Andy P, Marioni, John C, Ponting, Chris P, Holländer, Georg A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490013/
https://www.ncbi.nlm.nih.gov/pubmed/32840480
http://dx.doi.org/10.7554/eLife.56221

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