The Role of PON1 Variants in Disease Susceptibility in a Turkish Population

Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genot...

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Autores principales: Abudayyak, Mahmoud, Boran, Tuğçe, Tukel, Rumeysa, Oztas, Ezgi, Özhan, Gül
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490120/
https://www.ncbi.nlm.nih.gov/pubmed/32939514
http://dx.doi.org/10.1055/s-0040-1715568
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author Abudayyak, Mahmoud
Boran, Tuğçe
Tukel, Rumeysa
Oztas, Ezgi
Özhan, Gül
author_facet Abudayyak, Mahmoud
Boran, Tuğçe
Tukel, Rumeysa
Oztas, Ezgi
Özhan, Gül
author_sort Abudayyak, Mahmoud
collection PubMed
description Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genotype. PON1 genotypes were evaluated with the development of pancreatitis, colorectal cancer, and hypothyroidism in a hospital-based, case-control study. Individuals with rs662 G allele had a two-fold risk of developing hypothyroidism. A weak association was found between rs854560 T allele and pancreatitis. The results were preliminary. Further studies with a larger number and detailed biochemical parameters are needed.
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spelling pubmed-74901202020-09-15 The Role of PON1 Variants in Disease Susceptibility in a Turkish Population Abudayyak, Mahmoud Boran, Tuğçe Tukel, Rumeysa Oztas, Ezgi Özhan, Gül Glob Med Genet Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genotype. PON1 genotypes were evaluated with the development of pancreatitis, colorectal cancer, and hypothyroidism in a hospital-based, case-control study. Individuals with rs662 G allele had a two-fold risk of developing hypothyroidism. A weak association was found between rs854560 T allele and pancreatitis. The results were preliminary. Further studies with a larger number and detailed biochemical parameters are needed. Georg Thieme Verlag KG 2020-08 2020-08-31 /pmc/articles/PMC7490120/ /pubmed/32939514 http://dx.doi.org/10.1055/s-0040-1715568 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ). https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abudayyak, Mahmoud
Boran, Tuğçe
Tukel, Rumeysa
Oztas, Ezgi
Özhan, Gül
The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
title The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
title_full The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
title_fullStr The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
title_full_unstemmed The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
title_short The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
title_sort role of pon1 variants in disease susceptibility in a turkish population
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490120/
https://www.ncbi.nlm.nih.gov/pubmed/32939514
http://dx.doi.org/10.1055/s-0040-1715568
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