Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism

The aim of this study was to investigate the frequency of methylenetetrahydrofolate reductase ( MTHFR) gene polymorphisms in Georgian females with hypothyroidism. Thirty-four patients and 29 healthy individuals were recruited in this study. Polymerase chain reaction-restriction fragment length polym...

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Autores principales: Kvaratskhelia, Tamar, Abzianidze, Elene, Asatiani, Ketevan, Kvintradze, Merab, Surmava, Sandro, Kvaratskhelia, Eka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490122/
https://www.ncbi.nlm.nih.gov/pubmed/32939515
http://dx.doi.org/10.1055/s-0040-1714091
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author Kvaratskhelia, Tamar
Abzianidze, Elene
Asatiani, Ketevan
Kvintradze, Merab
Surmava, Sandro
Kvaratskhelia, Eka
author_facet Kvaratskhelia, Tamar
Abzianidze, Elene
Asatiani, Ketevan
Kvintradze, Merab
Surmava, Sandro
Kvaratskhelia, Eka
author_sort Kvaratskhelia, Tamar
collection PubMed
description The aim of this study was to investigate the frequency of methylenetetrahydrofolate reductase ( MTHFR) gene polymorphisms in Georgian females with hypothyroidism. Thirty-four patients and 29 healthy individuals were recruited in this study. Polymerase chain reaction-restriction fragment length polymorphism analyses were used for genotyping of MTHFR polymorphisms. The results of this study suggest that the MTHFR C677T variant was significantly associated with hypothyroidism. In addition, in individuals with T allele risk of hypothyroidism significantly increased. Combination of CT/AA genotypes was more prevalent in the hypothyroid patients than in the control group. Thus, C677T polymorphism could be a possible genetic factor contributing to the pathophysiology of hypothyroidism, possibly through hyperhomocysteinemia.
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spelling pubmed-74901222020-09-15 Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism Kvaratskhelia, Tamar Abzianidze, Elene Asatiani, Ketevan Kvintradze, Merab Surmava, Sandro Kvaratskhelia, Eka Glob Med Genet The aim of this study was to investigate the frequency of methylenetetrahydrofolate reductase ( MTHFR) gene polymorphisms in Georgian females with hypothyroidism. Thirty-four patients and 29 healthy individuals were recruited in this study. Polymerase chain reaction-restriction fragment length polymorphism analyses were used for genotyping of MTHFR polymorphisms. The results of this study suggest that the MTHFR C677T variant was significantly associated with hypothyroidism. In addition, in individuals with T allele risk of hypothyroidism significantly increased. Combination of CT/AA genotypes was more prevalent in the hypothyroid patients than in the control group. Thus, C677T polymorphism could be a possible genetic factor contributing to the pathophysiology of hypothyroidism, possibly through hyperhomocysteinemia. Georg Thieme Verlag KG 2020-08 2020-07-20 /pmc/articles/PMC7490122/ /pubmed/32939515 http://dx.doi.org/10.1055/s-0040-1714091 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ). https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Kvaratskhelia, Tamar
Abzianidze, Elene
Asatiani, Ketevan
Kvintradze, Merab
Surmava, Sandro
Kvaratskhelia, Eka
Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism
title Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism
title_full Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism
title_fullStr Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism
title_full_unstemmed Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism
title_short Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism
title_sort methylenetetrahydrofolate reductase (mthfr) c677t and a1298c polymorphisms in georgian females with hypothyroidism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490122/
https://www.ncbi.nlm.nih.gov/pubmed/32939515
http://dx.doi.org/10.1055/s-0040-1714091
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