Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer

Background  Cancer and diabetes have a tremendous impact on health globally. This study aimed to evaluate the KRAS gene in colon cancer tissues obtained from patients with type 2 diabetes mellitus (T2DM). Materials and Methods  Data from 315 cases (156 colon diabetics and 159 patients were nondiabet...

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Detalles Bibliográficos
Autores principales: Al-Qahtani, Wedad Saeed, Al-Olayan, Ebtesam, Albani, Fatimah Gh., Suliman, Rania Saad, Aljarba, Nada Hamad, Al-Humaidhi, E.M., Almurshedi, Alanood S., Domiaty, Dalia Mostafa, Alduwish, Manal Abdullah, Al-Otaibi, Aljohara M., Elasbali, Abdelbaset Mohamed, Ahmed, Hussain Gadelkarim, Almutlaq, Bassam Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490123/
https://www.ncbi.nlm.nih.gov/pubmed/32939513
http://dx.doi.org/10.1055/s-0040-1714415
Descripción
Sumario:Background  Cancer and diabetes have a tremendous impact on health globally. This study aimed to evaluate the KRAS gene in colon cancer tissues obtained from patients with type 2 diabetes mellitus (T2DM). Materials and Methods  Data from 315 cases (156 colon diabetics and 159 patients were nondiabetics) were retrospectively retrieved. mRNA from surgically resected colon cancer tumors were also retrieved. Results  The expression of KRAS mRNA was significantly higher in patients afflicted with T2DM than nondiabetic patients. The KRAS mRNA levels were significantly amplified from primary to metastatic lesions ( p  < 0.001). Conclusion  The association between T2DM and colon cancer was well-established in the present study.

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