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Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer
Background Cancer and diabetes have a tremendous impact on health globally. This study aimed to evaluate the KRAS gene in colon cancer tissues obtained from patients with type 2 diabetes mellitus (T2DM). Materials and Methods Data from 315 cases (156 colon diabetics and 159 patients were nondiabet...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Georg Thieme Verlag KG
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490123/ https://www.ncbi.nlm.nih.gov/pubmed/32939513 http://dx.doi.org/10.1055/s-0040-1714415 |
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| author | Al-Qahtani, Wedad Saeed Al-Olayan, Ebtesam Albani, Fatimah Gh. Suliman, Rania Saad Aljarba, Nada Hamad Al-Humaidhi, E.M. Almurshedi, Alanood S. Domiaty, Dalia Mostafa Alduwish, Manal Abdullah Al-Otaibi, Aljohara M. Elasbali, Abdelbaset Mohamed Ahmed, Hussain Gadelkarim Almutlaq, Bassam Ahmed |
| author_facet | Al-Qahtani, Wedad Saeed Al-Olayan, Ebtesam Albani, Fatimah Gh. Suliman, Rania Saad Aljarba, Nada Hamad Al-Humaidhi, E.M. Almurshedi, Alanood S. Domiaty, Dalia Mostafa Alduwish, Manal Abdullah Al-Otaibi, Aljohara M. Elasbali, Abdelbaset Mohamed Ahmed, Hussain Gadelkarim Almutlaq, Bassam Ahmed |
| author_sort | Al-Qahtani, Wedad Saeed |
| collection | PubMed |
| description | Background Cancer and diabetes have a tremendous impact on health globally. This study aimed to evaluate the KRAS gene in colon cancer tissues obtained from patients with type 2 diabetes mellitus (T2DM). Materials and Methods Data from 315 cases (156 colon diabetics and 159 patients were nondiabetics) were retrospectively retrieved. mRNA from surgically resected colon cancer tumors were also retrieved. Results The expression of KRAS mRNA was significantly higher in patients afflicted with T2DM than nondiabetic patients. The KRAS mRNA levels were significantly amplified from primary to metastatic lesions ( p < 0.001). Conclusion The association between T2DM and colon cancer was well-established in the present study. |
| format | Online Article Text |
| id | pubmed-7490123 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Georg Thieme Verlag KG |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74901232020-09-15 Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer Al-Qahtani, Wedad Saeed Al-Olayan, Ebtesam Albani, Fatimah Gh. Suliman, Rania Saad Aljarba, Nada Hamad Al-Humaidhi, E.M. Almurshedi, Alanood S. Domiaty, Dalia Mostafa Alduwish, Manal Abdullah Al-Otaibi, Aljohara M. Elasbali, Abdelbaset Mohamed Ahmed, Hussain Gadelkarim Almutlaq, Bassam Ahmed Glob Med Genet Background Cancer and diabetes have a tremendous impact on health globally. This study aimed to evaluate the KRAS gene in colon cancer tissues obtained from patients with type 2 diabetes mellitus (T2DM). Materials and Methods Data from 315 cases (156 colon diabetics and 159 patients were nondiabetics) were retrospectively retrieved. mRNA from surgically resected colon cancer tumors were also retrieved. Results The expression of KRAS mRNA was significantly higher in patients afflicted with T2DM than nondiabetic patients. The KRAS mRNA levels were significantly amplified from primary to metastatic lesions ( p < 0.001). Conclusion The association between T2DM and colon cancer was well-established in the present study. Georg Thieme Verlag KG 2020-08 2020-08-31 /pmc/articles/PMC7490123/ /pubmed/32939513 http://dx.doi.org/10.1055/s-0040-1714415 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ). https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Al-Qahtani, Wedad Saeed Al-Olayan, Ebtesam Albani, Fatimah Gh. Suliman, Rania Saad Aljarba, Nada Hamad Al-Humaidhi, E.M. Almurshedi, Alanood S. Domiaty, Dalia Mostafa Alduwish, Manal Abdullah Al-Otaibi, Aljohara M. Elasbali, Abdelbaset Mohamed Ahmed, Hussain Gadelkarim Almutlaq, Bassam Ahmed Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer |
| title |
Utility of
KRAS
Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer
|
| title_full |
Utility of
KRAS
Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer
|
| title_fullStr |
Utility of
KRAS
Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer
|
| title_full_unstemmed |
Utility of
KRAS
Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer
|
| title_short |
Utility of
KRAS
Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer
|
| title_sort | utility of
kras
gene and clinicopathological features in the assessment of the risk of type 2 diabetes in the etiology of colon cancer |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490123/ https://www.ncbi.nlm.nih.gov/pubmed/32939513 http://dx.doi.org/10.1055/s-0040-1714415 |
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