Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells

Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, the immunosuppressive factors induced by radiation on tumor cells remain to be identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast...

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Detalles Bibliográficos
Autores principales: Candas-Green, Demet, Xie, Bowen, Huang, Jie, Fan, Ming, Wang, Aijun, Menaa, Cheikh, Zhang, Yanhong, Zhang, Lu, Jing, Di, Azghadi, Soheila, Zhou, Weibing, Liu, Lin, Jiang, Nian, Li, Tao, Gao, Tianyi, Sweeney, Colleen, Shen, Rulong, Lin, Tzu-yin, Pan, Chong-xian, Ozpiskin, Omer M., Woloschak, Gayle, Grdina, David J., Vaughan, Andrew T., Wang, Ji Ming, Xia, Shuli, Monjazeb, Arta M., Murphy, William J., Sun, Lun-Quan, Chen, Hong-Wu, Lam, Kit S., Weichselbaum, Ralph R., Li, Jian Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490264/
https://www.ncbi.nlm.nih.gov/pubmed/32929084
http://dx.doi.org/10.1038/s41467-020-18245-7

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