Inhibition of the activation of γδT17 cells through PPARγ–PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid

Type-17 immune response, mediated mainly by IL-17, plays a critical role in ulcerative colitis. Previously, we showed that madecassic acid (MA), the main active ingredient of Centella asiatica herbs for anti-colitis effect, ameliorated dextran sulfate sodium (DSS)-induced mouse colitis through reduc...

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Detalles Bibliográficos
Autores principales: Yun, Xinming, Fang, Yulai, Lv, Changjun, Qiao, Simiao, Tao, Yu, Dai, Yue, Xia, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490397/
https://www.ncbi.nlm.nih.gov/pubmed/32929062
http://dx.doi.org/10.1038/s41419-020-02969-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490397/
https://www.ncbi.nlm.nih.gov/pubmed/32929062
http://dx.doi.org/10.1038/s41419-020-02969-x

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