The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs

Dysregulation of inositol-requiring enzyme 1 (IRE1), the primary transducer of Unfolded Protein Response (UPR), has been observed in tumor initiation and progression, but the underlying mechanism remains to be further elucidated. In this study, we identified that the IRE1 gene is frequently amplifie...

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Detalles Bibliográficos
Autores principales: Zhang, Kezhong, Liu, Hui, Song, Zhenfeng, Jiang, Yuanyuan, Kim, Hyunbae, Samavati, Lobelia, Nguyen, Hien M., Yang, Zeng-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490531/
https://www.ncbi.nlm.nih.gov/pubmed/32911332
http://dx.doi.org/10.1016/j.isci.2020.101503

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