Cargando…

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation

NRF2 (NFE2L2) is a cytoprotective transcription factor associated with >60 human diseases, adverse drug reactions and therapeutic resistance. To provide insight into the complex regulation of NRF2 responses, 1962 predicted NRF2-partner interactions were systematically tested to generate an experi...

Descripción completa

Detalles Bibliográficos
Autores principales: Poh, Jonathan, Ponsford, Amy H., Boyd, James, Woodsmith, Jonathan, Stelzl, Ulrich, Wanker, Erich, Harper, Nicholas, MacEwan, David, Sanderson, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490560/
https://www.ncbi.nlm.nih.gov/pubmed/32911434
http://dx.doi.org/10.1016/j.redox.2020.101686