Safety and Efficacy of an Immune Cell-Specific Chimeric Promoter in Regulating Anti-PD-1 Antibody Expression in CAR T Cells

T cells modified to co-express cytokine or other factors with chimeric antigen receptor (CAR) can induce substantial and persistent increases in antitumor capacity in vivo. However, the uncontrolled expression of cytokines or factors can lead to the overactivation of immune cells, causing severe adv...

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Detalles Bibliográficos
Autores principales: Fang, Yuan, Zhang, Yajun, Guo, Chuanxin, Chen, Chumeng, Gao, Haixia, Zhou, Xiumei, Liu, Tao, Qian, Qijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490636/
https://www.ncbi.nlm.nih.gov/pubmed/32995356
http://dx.doi.org/10.1016/j.omtm.2020.08.008

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