Caspase-8 mediates inflammation and disease in rodent malaria

Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei...

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Detalles Bibliográficos
Autores principales: Pereira, Larissa M. N., Assis, Patrícia A., de Araújo, Natalia M., Durso, Danielle F., Junqueira, Caroline, Ataíde, Marco Antônio, Pereira, Dhelio B., Lien, Egil, Fitzgerald, Katherine A., Zamboni, Dario S., Golenbock, Douglas T., Gazzinelli, Ricardo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490701/
https://www.ncbi.nlm.nih.gov/pubmed/32929083
http://dx.doi.org/10.1038/s41467-020-18295-x

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