Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection

Ochratoxin A (OTA) is a mycotoxin that is widespread throughout the world. It contaminates foods such as vegetables, fruits, and rice. It harms human health and has potential carcinogenic effects. The G-quadruplex (G4) is a tetraplexed DNA structure generated from guanine-rich DNA that has found eme...

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Autores principales: Nao, Sang-Cuo, Wu, Ke-Jia, Wang, Wanhe, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490745/
https://www.ncbi.nlm.nih.gov/pubmed/33088800
http://dx.doi.org/10.3389/fchem.2020.00767
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author Nao, Sang-Cuo
Wu, Ke-Jia
Wang, Wanhe
Leung, Chung-Hang
Ma, Dik-Lung
author_facet Nao, Sang-Cuo
Wu, Ke-Jia
Wang, Wanhe
Leung, Chung-Hang
Ma, Dik-Lung
author_sort Nao, Sang-Cuo
collection PubMed
description Ochratoxin A (OTA) is a mycotoxin that is widespread throughout the world. It contaminates foods such as vegetables, fruits, and rice. It harms human health and has potential carcinogenic effects. The G-quadruplex (G4) is a tetraplexed DNA structure generated from guanine-rich DNA that has found emerging use in aptamer-based sensing systems. This review outlines the status of OTA contamination and conventional detection methods for OTA. Various G4-based methods to detect OTA developed in recent years are summarized along with their advantages and disadvantages compared to existing approaches.
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spelling pubmed-74907452020-10-20 Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection Nao, Sang-Cuo Wu, Ke-Jia Wang, Wanhe Leung, Chung-Hang Ma, Dik-Lung Front Chem Chemistry Ochratoxin A (OTA) is a mycotoxin that is widespread throughout the world. It contaminates foods such as vegetables, fruits, and rice. It harms human health and has potential carcinogenic effects. The G-quadruplex (G4) is a tetraplexed DNA structure generated from guanine-rich DNA that has found emerging use in aptamer-based sensing systems. This review outlines the status of OTA contamination and conventional detection methods for OTA. Various G4-based methods to detect OTA developed in recent years are summarized along with their advantages and disadvantages compared to existing approaches. Frontiers Media S.A. 2020-09-01 /pmc/articles/PMC7490745/ /pubmed/33088800 http://dx.doi.org/10.3389/fchem.2020.00767 Text en Copyright © 2020 Nao, Wu, Wang, Leung and Ma. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Nao, Sang-Cuo
Wu, Ke-Jia
Wang, Wanhe
Leung, Chung-Hang
Ma, Dik-Lung
Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection
title Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection
title_full Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection
title_fullStr Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection
title_full_unstemmed Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection
title_short Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection
title_sort recent progress and development of g-quadruplex-based luminescent assays for ochratoxin a detection
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490745/
https://www.ncbi.nlm.nih.gov/pubmed/33088800
http://dx.doi.org/10.3389/fchem.2020.00767
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