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Role of Bicarbonates and Mannitol in Rhabdomyolysis: A Comprehensive Review

Rhabdomyolysis is characterized by rapid muscle breakdown and release of intracellular muscle components into the circulation. Acute renal injury is the most common and fatal complication of rhabdomyolysis. The current literature emphasizes the importance of preventing rhabdomyolysis and finding the...

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Autores principales: Somagutta, Manoj R, Pagad, Sukrut, Sridharan, Saijanakan, Nanthakumaran, Saruja, Arnold, Ashley A, May, Vanessa, Malik, Bilal Haider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490772/
https://www.ncbi.nlm.nih.gov/pubmed/32944457
http://dx.doi.org/10.7759/cureus.9742
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author Somagutta, Manoj R
Pagad, Sukrut
Sridharan, Saijanakan
Nanthakumaran, Saruja
Arnold, Ashley A
May, Vanessa
Malik, Bilal Haider
author_facet Somagutta, Manoj R
Pagad, Sukrut
Sridharan, Saijanakan
Nanthakumaran, Saruja
Arnold, Ashley A
May, Vanessa
Malik, Bilal Haider
author_sort Somagutta, Manoj R
collection PubMed
description Rhabdomyolysis is characterized by rapid muscle breakdown and release of intracellular muscle components into the circulation. Acute renal injury is the most common and fatal complication of rhabdomyolysis. The current literature emphasizes the importance of preventing rhabdomyolysis and finding the benefits of sodium bicarbonates and mannitol in its prevention. A PubMed database search for the keywords "Rhabdomyolysis," "Sodium bicarbonate use in rhabdomyolysis," "Mannitol use in rhabdomyolysis," and a Medical Subject Headings (MeSH) search using the keyword "Rhabdomyolysis; Acute Kidney Injury (Subheading-Prevention and control)" generated 10,005 articles overall. After a thorough application of inclusion/exclusion criteria, 37 relevant studies were selected for this literature study. This analysis demonstrates that aggressive early volume resuscitation with normal saline should continue being the principal focus of therapy, and the use of sodium bicarbonate and mannitol in practical situations is not entirely justified. This article also emphasizes the need for future research on this topic and provides recommendations for future research. 
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spelling pubmed-74907722020-09-16 Role of Bicarbonates and Mannitol in Rhabdomyolysis: A Comprehensive Review Somagutta, Manoj R Pagad, Sukrut Sridharan, Saijanakan Nanthakumaran, Saruja Arnold, Ashley A May, Vanessa Malik, Bilal Haider Cureus Internal Medicine Rhabdomyolysis is characterized by rapid muscle breakdown and release of intracellular muscle components into the circulation. Acute renal injury is the most common and fatal complication of rhabdomyolysis. The current literature emphasizes the importance of preventing rhabdomyolysis and finding the benefits of sodium bicarbonates and mannitol in its prevention. A PubMed database search for the keywords "Rhabdomyolysis," "Sodium bicarbonate use in rhabdomyolysis," "Mannitol use in rhabdomyolysis," and a Medical Subject Headings (MeSH) search using the keyword "Rhabdomyolysis; Acute Kidney Injury (Subheading-Prevention and control)" generated 10,005 articles overall. After a thorough application of inclusion/exclusion criteria, 37 relevant studies were selected for this literature study. This analysis demonstrates that aggressive early volume resuscitation with normal saline should continue being the principal focus of therapy, and the use of sodium bicarbonate and mannitol in practical situations is not entirely justified. This article also emphasizes the need for future research on this topic and provides recommendations for future research.  Cureus 2020-08-14 /pmc/articles/PMC7490772/ /pubmed/32944457 http://dx.doi.org/10.7759/cureus.9742 Text en Copyright © 2020, Somagutta et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Somagutta, Manoj R
Pagad, Sukrut
Sridharan, Saijanakan
Nanthakumaran, Saruja
Arnold, Ashley A
May, Vanessa
Malik, Bilal Haider
Role of Bicarbonates and Mannitol in Rhabdomyolysis: A Comprehensive Review
title Role of Bicarbonates and Mannitol in Rhabdomyolysis: A Comprehensive Review
title_full Role of Bicarbonates and Mannitol in Rhabdomyolysis: A Comprehensive Review
title_fullStr Role of Bicarbonates and Mannitol in Rhabdomyolysis: A Comprehensive Review
title_full_unstemmed Role of Bicarbonates and Mannitol in Rhabdomyolysis: A Comprehensive Review
title_short Role of Bicarbonates and Mannitol in Rhabdomyolysis: A Comprehensive Review
title_sort role of bicarbonates and mannitol in rhabdomyolysis: a comprehensive review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490772/
https://www.ncbi.nlm.nih.gov/pubmed/32944457
http://dx.doi.org/10.7759/cureus.9742
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