Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway

BACKGROUND: Elderly populations are susceptible to critical limb ischemia (CLI), but conventional treatments cannot significantly decrease amputation and mortality. Although exercise is an effective “non-pharmacological medicine” targeting mitochondria to improve skeletal muscle function, few studie...

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Detalles Bibliográficos
Autores principales: He, Wuyang, Wang, Peng, Chen, Qingwei, Li, Chunqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490877/
https://www.ncbi.nlm.nih.gov/pubmed/32933582
http://dx.doi.org/10.1186/s13395-020-00245-2

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