Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark

Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modifications. NATs are dysregulated in various types of cancer, and an increasing number of stu...

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Detalles Bibliográficos
Autores principales: Zhao, Shanshan, Zhang, Xue, Chen, Shuo, Zhang, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490906/
https://www.ncbi.nlm.nih.gov/pubmed/32928281
http://dx.doi.org/10.1186/s13046-020-01700-0
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author Zhao, Shanshan
Zhang, Xue
Chen, Shuo
Zhang, Song
author_facet Zhao, Shanshan
Zhang, Xue
Chen, Shuo
Zhang, Song
author_sort Zhao, Shanshan
collection PubMed
description Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modifications. NATs are dysregulated in various types of cancer, and an increasing number of studies focusing on NATs as pivotal regulators of the hallmarks of cancer and as promising candidates for cancer therapy are just beginning to unravel the mystery. Here, we summarize the existing knowledge on NATs to highlight their underlying mechanisms of functions in cancer biology, discuss their potential roles in therapeutic application, and explore future research directions.
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spelling pubmed-74909062020-09-16 Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark Zhao, Shanshan Zhang, Xue Chen, Shuo Zhang, Song J Exp Clin Cancer Res Review Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modifications. NATs are dysregulated in various types of cancer, and an increasing number of studies focusing on NATs as pivotal regulators of the hallmarks of cancer and as promising candidates for cancer therapy are just beginning to unravel the mystery. Here, we summarize the existing knowledge on NATs to highlight their underlying mechanisms of functions in cancer biology, discuss their potential roles in therapeutic application, and explore future research directions. BioMed Central 2020-09-14 /pmc/articles/PMC7490906/ /pubmed/32928281 http://dx.doi.org/10.1186/s13046-020-01700-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhao, Shanshan
Zhang, Xue
Chen, Shuo
Zhang, Song
Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
title Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
title_full Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
title_fullStr Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
title_full_unstemmed Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
title_short Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
title_sort natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490906/
https://www.ncbi.nlm.nih.gov/pubmed/32928281
http://dx.doi.org/10.1186/s13046-020-01700-0
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