Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial

The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in car...

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Autores principales: Tang, Ivan, Turnbull, Chris D, Sen, Dushendree, Craig, Sonya, Kohler, Malcolm, Stradling, John R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490925/
https://www.ncbi.nlm.nih.gov/pubmed/32928788
http://dx.doi.org/10.1136/bmjresp-2020-000742
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author Tang, Ivan
Turnbull, Chris D
Sen, Dushendree
Craig, Sonya
Kohler, Malcolm
Stradling, John R
author_facet Tang, Ivan
Turnbull, Chris D
Sen, Dushendree
Craig, Sonya
Kohler, Malcolm
Stradling, John R
author_sort Tang, Ivan
collection PubMed
description The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in cardiovascular events with CPAP therapy. We now present long-term MOSAIC study follow-up data. Median (first quartile, third quartile) follow-up was 5.0 (2.2, 5.0) and 3.7 (1.5, 5.0) years for CPAP and standard care, respectively. Compared to standard care, CPAP had no statistically significant effect on the risk of cardiovascular events (HR=0.83, p=0.54, 95% CI 0.46–1.51).
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spelling pubmed-74909252020-09-25 Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial Tang, Ivan Turnbull, Chris D Sen, Dushendree Craig, Sonya Kohler, Malcolm Stradling, John R BMJ Open Respir Res Perspective The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in cardiovascular events with CPAP therapy. We now present long-term MOSAIC study follow-up data. Median (first quartile, third quartile) follow-up was 5.0 (2.2, 5.0) and 3.7 (1.5, 5.0) years for CPAP and standard care, respectively. Compared to standard care, CPAP had no statistically significant effect on the risk of cardiovascular events (HR=0.83, p=0.54, 95% CI 0.46–1.51). BMJ Publishing Group 2020-09-14 /pmc/articles/PMC7490925/ /pubmed/32928788 http://dx.doi.org/10.1136/bmjresp-2020-000742 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Perspective
Tang, Ivan
Turnbull, Chris D
Sen, Dushendree
Craig, Sonya
Kohler, Malcolm
Stradling, John R
Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
title Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
title_full Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
title_fullStr Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
title_full_unstemmed Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
title_short Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
title_sort effect of cpap on cardiovascular events in minimally symptomatic osa: long-term follow-up of the mosaic randomised controlled trial
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490925/
https://www.ncbi.nlm.nih.gov/pubmed/32928788
http://dx.doi.org/10.1136/bmjresp-2020-000742
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