Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors

• Cure rates are high for choriocarcinoma, however chemoresistant disease often leads to death. • High expression of PD-L1 suggests a role for checkpoint inhibitors in choriocarcinoma. • Pembrolizumab should be considered for salvage therapy for chemoresistant choriocarcinoma.

Detalles Bibliográficos
Autores principales: Clair, Kiran H., Gallegos, Nicolas, Bristow, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490982/
https://www.ncbi.nlm.nih.gov/pubmed/32964090
http://dx.doi.org/10.1016/j.gore.2020.100625
_version_ 1783582128966991872
author Clair, Kiran H.
Gallegos, Nicolas
Bristow, Robert E.
author_facet Clair, Kiran H.
Gallegos, Nicolas
Bristow, Robert E.
author_sort Clair, Kiran H.
collection PubMed
description • Cure rates are high for choriocarcinoma, however chemoresistant disease often leads to death. • High expression of PD-L1 suggests a role for checkpoint inhibitors in choriocarcinoma. • Pembrolizumab should be considered for salvage therapy for chemoresistant choriocarcinoma.
format Online
Article
Text
id pubmed-7490982
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-74909822020-09-21 Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors Clair, Kiran H. Gallegos, Nicolas Bristow, Robert E. Gynecol Oncol Rep Case Report • Cure rates are high for choriocarcinoma, however chemoresistant disease often leads to death. • High expression of PD-L1 suggests a role for checkpoint inhibitors in choriocarcinoma. • Pembrolizumab should be considered for salvage therapy for chemoresistant choriocarcinoma. Elsevier 2020-09-01 /pmc/articles/PMC7490982/ /pubmed/32964090 http://dx.doi.org/10.1016/j.gore.2020.100625 Text en © 2020 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Clair, Kiran H.
Gallegos, Nicolas
Bristow, Robert E.
Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors
title Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors
title_full Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors
title_fullStr Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors
title_full_unstemmed Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors
title_short Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors
title_sort successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: a case for immune checkpoint salvage therapy in trophoblastic tumors
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490982/
https://www.ncbi.nlm.nih.gov/pubmed/32964090
http://dx.doi.org/10.1016/j.gore.2020.100625
work_keys_str_mv AT clairkiranh successfultreatmentofmetastaticrefractorygestationalchoriocarcinomawithpembrolizumabacaseforimmunecheckpointsalvagetherapyintrophoblastictumors
AT gallegosnicolas successfultreatmentofmetastaticrefractorygestationalchoriocarcinomawithpembrolizumabacaseforimmunecheckpointsalvagetherapyintrophoblastictumors
AT bristowroberte successfultreatmentofmetastaticrefractorygestationalchoriocarcinomawithpembrolizumabacaseforimmunecheckpointsalvagetherapyintrophoblastictumors

Ejemplares similares