Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)

Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GRE...

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Autores principales: Grither, Whitney R., Dickson, Brendan C., Fuh, Katherine C., Hagemann, Ian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490989/
https://www.ncbi.nlm.nih.gov/pubmed/32964092
http://dx.doi.org/10.1016/j.gore.2020.100636
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author Grither, Whitney R.
Dickson, Brendan C.
Fuh, Katherine C.
Hagemann, Ian S.
author_facet Grither, Whitney R.
Dickson, Brendan C.
Fuh, Katherine C.
Hagemann, Ian S.
author_sort Grither, Whitney R.
collection PubMed
description Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1–NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses.
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spelling pubmed-74909892020-09-21 Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT) Grither, Whitney R. Dickson, Brendan C. Fuh, Katherine C. Hagemann, Ian S. Gynecol Oncol Rep Case Report Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1–NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses. Elsevier 2020-09-06 /pmc/articles/PMC7490989/ /pubmed/32964092 http://dx.doi.org/10.1016/j.gore.2020.100636 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Grither, Whitney R.
Dickson, Brendan C.
Fuh, Katherine C.
Hagemann, Ian S.
Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)
title Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)
title_full Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)
title_fullStr Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)
title_full_unstemmed Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)
title_short Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)
title_sort detection of a somatic greb1-ncoa1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (utrosct)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490989/
https://www.ncbi.nlm.nih.gov/pubmed/32964092
http://dx.doi.org/10.1016/j.gore.2020.100636
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