Association of programmed death ligand 1 expression with prognosis among patients with ten uncommon advanced cancers

AIM: PD-L1 expression and high levels of microsatellite instability (MSI-H) may predict response to checkpoint inhibitors, but their prevalence and prognostic value are unknown in many cancers. METHODS: We retrospectively evaluated PD-L1 combined positive score (CPS) and MSI-H and their association...

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Detalles Bibliográficos
Autores principales: Steiniche, Torben, Ladekarl, Morten, Georgsen, Jeanette Bæhr, Andreasen, Simon, Busch-Sørensen, Michael, Zhou, Wei, Marton, Matthew J, Pruitt, Scott K, Jin, Fan, Liaw, Kai-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491035/
https://www.ncbi.nlm.nih.gov/pubmed/32983568
http://dx.doi.org/10.2144/fsoa-2020-0063
Descripción
Sumario:AIM: PD-L1 expression and high levels of microsatellite instability (MSI-H) may predict response to checkpoint inhibitors, but their prevalence and prognostic value are unknown in many cancers. METHODS: We retrospectively evaluated PD-L1 combined positive score (CPS) and MSI-H and their association with clinical outcomes among patients with ten advanced uncommon cancers. RESULTS: 398 of 426 patients (93%) had a valid PD-L1 result; most (242; 61%) had CPS ≥1. Prevalence of MSI-H tumors was 8/360. Median overall survival was shorter among patients with PD-L1 CPS ≥1 tumors after first-line treatment (23.0 vs 39.7 months, p = 0.014). CONCLUSION: PD-L1 was commonly expressed in solid tumors, and CPS ≥1 was associated with shorter overall survival. Prevalence of MSI-H was low.

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