Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients

Amyotrophic lateral sclerosis is a disease characterized by progressive paralysis and death. Most ALS-cases are sporadic (sALS) and patient heterogeneity poses challenges for effective therapies. Applying metabolite profiling on 77-sALS patient-derived-fibroblasts and 43-controls, we found ~25% of s...

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Detalles Bibliográficos
Autores principales: Chen, Qiuying, Konrad, Csaba, Sandhu, Davinder, Roychoudhury, Dipa, Schwartz, Benjamin I., Cheng, Roger R., Bredvik, Kirsten, Kawamata, Hibiki, Calder, Elizabeth L., Studer, Lorenz, Fischer, Steven.M., Manfredi, Giovanni, Gross, Steven.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491150/
https://www.ncbi.nlm.nih.gov/pubmed/32745521
http://dx.doi.org/10.1016/j.nbd.2020.105025

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