Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circular DNA have been considered an effective biomarker of cancer pathogenesis. Multiple report...

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Autores principales: Yan, Yuanliang, Guo, Guijie, Huang, Jinzhou, Gao, Ming, Zhu, Qian, Zeng, Shuangshuang, Gong, Zhicheng, Xu, Zhijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491193/
https://www.ncbi.nlm.nih.gov/pubmed/32928268
http://dx.doi.org/10.1186/s13045-020-00960-9
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author Yan, Yuanliang
Guo, Guijie
Huang, Jinzhou
Gao, Ming
Zhu, Qian
Zeng, Shuangshuang
Gong, Zhicheng
Xu, Zhijie
author_facet Yan, Yuanliang
Guo, Guijie
Huang, Jinzhou
Gao, Ming
Zhu, Qian
Zeng, Shuangshuang
Gong, Zhicheng
Xu, Zhijie
author_sort Yan, Yuanliang
collection PubMed
description Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circular DNA have been considered an effective biomarker of cancer pathogenesis. Multiple reports have demonstrated that the amplification of oncogenes and therapeutic resistance genes located on extrachromosomal DNA is a frequent event that drives intratumoral genetic heterogeneity and provides a potential evolutionary advantage. This review highlights the current understanding of the extrachromosomal circular DNA present in the tissues and circulation of patients with advanced cancers and provides a detailed discussion of their substantial roles in tumor regulation. Confirming the presence of cancer-related extrachromosomal circular DNA would provide a putative testing strategy for the precision diagnosis and treatment of human malignancies in clinical practice.
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spelling pubmed-74911932020-09-16 Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance Yan, Yuanliang Guo, Guijie Huang, Jinzhou Gao, Ming Zhu, Qian Zeng, Shuangshuang Gong, Zhicheng Xu, Zhijie J Hematol Oncol Review Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circular DNA have been considered an effective biomarker of cancer pathogenesis. Multiple reports have demonstrated that the amplification of oncogenes and therapeutic resistance genes located on extrachromosomal DNA is a frequent event that drives intratumoral genetic heterogeneity and provides a potential evolutionary advantage. This review highlights the current understanding of the extrachromosomal circular DNA present in the tissues and circulation of patients with advanced cancers and provides a detailed discussion of their substantial roles in tumor regulation. Confirming the presence of cancer-related extrachromosomal circular DNA would provide a putative testing strategy for the precision diagnosis and treatment of human malignancies in clinical practice. BioMed Central 2020-09-14 /pmc/articles/PMC7491193/ /pubmed/32928268 http://dx.doi.org/10.1186/s13045-020-00960-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yan, Yuanliang
Guo, Guijie
Huang, Jinzhou
Gao, Ming
Zhu, Qian
Zeng, Shuangshuang
Gong, Zhicheng
Xu, Zhijie
Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
title Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
title_full Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
title_fullStr Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
title_full_unstemmed Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
title_short Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
title_sort current understanding of extrachromosomal circular dna in cancer pathogenesis and therapeutic resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491193/
https://www.ncbi.nlm.nih.gov/pubmed/32928268
http://dx.doi.org/10.1186/s13045-020-00960-9
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