Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients

Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were sligh...

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Autores principales: Gama, Wellington Mota, Oliveira, Lucas Barbosa, Chaves, Yury Oliveira, Ribeiro, Flavio, Almeida, Taynná Vernalha Rocha, Baptista, Barbara Jose Antunes, Santana, Monique Freire, Ferreira, Luis Carlos, Lacerda, Marcus Vinicius Guimaraes, Nogueira, Paulo Afonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491275/
https://www.ncbi.nlm.nih.gov/pubmed/32935750
http://dx.doi.org/10.1590/0074-02760200082
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author Gama, Wellington Mota
Oliveira, Lucas Barbosa
Chaves, Yury Oliveira
Ribeiro, Flavio
Almeida, Taynná Vernalha Rocha
Baptista, Barbara Jose Antunes
Santana, Monique Freire
Ferreira, Luis Carlos
Lacerda, Marcus Vinicius Guimaraes
Nogueira, Paulo Afonso
author_facet Gama, Wellington Mota
Oliveira, Lucas Barbosa
Chaves, Yury Oliveira
Ribeiro, Flavio
Almeida, Taynná Vernalha Rocha
Baptista, Barbara Jose Antunes
Santana, Monique Freire
Ferreira, Luis Carlos
Lacerda, Marcus Vinicius Guimaraes
Nogueira, Paulo Afonso
author_sort Gama, Wellington Mota
collection PubMed
description Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection.
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spelling pubmed-74912752020-09-21 Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients Gama, Wellington Mota Oliveira, Lucas Barbosa Chaves, Yury Oliveira Ribeiro, Flavio Almeida, Taynná Vernalha Rocha Baptista, Barbara Jose Antunes Santana, Monique Freire Ferreira, Luis Carlos Lacerda, Marcus Vinicius Guimaraes Nogueira, Paulo Afonso Mem Inst Oswaldo Cruz Short Communication Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection. Instituto Oswaldo Cruz, Ministério da Saúde 2020-09-14 /pmc/articles/PMC7491275/ /pubmed/32935750 http://dx.doi.org/10.1590/0074-02760200082 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Gama, Wellington Mota
Oliveira, Lucas Barbosa
Chaves, Yury Oliveira
Ribeiro, Flavio
Almeida, Taynná Vernalha Rocha
Baptista, Barbara Jose Antunes
Santana, Monique Freire
Ferreira, Luis Carlos
Lacerda, Marcus Vinicius Guimaraes
Nogueira, Paulo Afonso
Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
title Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
title_full Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
title_fullStr Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
title_full_unstemmed Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
title_short Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
title_sort increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in hiv/aids patients
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491275/
https://www.ncbi.nlm.nih.gov/pubmed/32935750
http://dx.doi.org/10.1590/0074-02760200082
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