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The triglyceride-glucose index predicts peripheral artery disease complexity

BACKGROUND/AIM: High levels of triglyceride (TG) and fasting blood glucose (FBG) values increase atherosclerosis risk. This study evaluates the relationship between peripheral artery disease (PAD) severity and complexity, as assessed by TransAtlantic InterSociety Consensus-II (TASC-II) classificatio...

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Autores principales: DURAN KARADUMAN, Bilge, AYHAN, Hüseyin, KELEŞ, Telat, BOZKURT, Engin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491281/
https://www.ncbi.nlm.nih.gov/pubmed/32718124
http://dx.doi.org/10.3906/sag-2006-180
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author DURAN KARADUMAN, Bilge
AYHAN, Hüseyin
KELEŞ, Telat
BOZKURT, Engin
author_facet DURAN KARADUMAN, Bilge
AYHAN, Hüseyin
KELEŞ, Telat
BOZKURT, Engin
author_sort DURAN KARADUMAN, Bilge
collection PubMed
description BACKGROUND/AIM: High levels of triglyceride (TG) and fasting blood glucose (FBG) values increase atherosclerosis risk. This study evaluates the relationship between peripheral artery disease (PAD) severity and complexity, as assessed by TransAtlantic InterSociety Consensus-II (TASC-II) classification and the triglyceride-glucose (TyG) index. MATERIALS AND METHODS: A total of 71 consecutive patients with PAD (males 93%, mean age 63.3 ± 9.7), who underwent percutaneous peripheral intervention were included retrospectively. The patients were divided into two groups according to the angiographically detected lesions. Those with TASC A-B lesions were included in Group 1, and those with TASC C-D lesions were included in Group 2. TyG index was calculated as formula: ln[fasting TG (mg/dL) × fasting plasma glucose (mg/dL)/2]. RESULTS: There were 40 patients in Group 1 (90.3% men, with a mean age of 63.6 ± 9.3 years) and 31 patients in Group 2 (96.8% men, with a mean age of 62.0 ± 8.6 years). In the majority of patients in both groups, the target vessels are iliac arteries and femoral arteries. In Group 2, platelet count and TyG index were significantly high, according to Group 1. The TyG index was significantly correlated with TASC-II, Rutherford category, HbA1c, and HDL-C. CONCLUSION: In this present study, we showed that the TyG index was an independent predictor of peripheral artery disease complexity, according to TASC-II classification, for the first time in the literature.
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spelling pubmed-74912812020-09-16 The triglyceride-glucose index predicts peripheral artery disease complexity DURAN KARADUMAN, Bilge AYHAN, Hüseyin KELEŞ, Telat BOZKURT, Engin Turk J Med Sci Article BACKGROUND/AIM: High levels of triglyceride (TG) and fasting blood glucose (FBG) values increase atherosclerosis risk. This study evaluates the relationship between peripheral artery disease (PAD) severity and complexity, as assessed by TransAtlantic InterSociety Consensus-II (TASC-II) classification and the triglyceride-glucose (TyG) index. MATERIALS AND METHODS: A total of 71 consecutive patients with PAD (males 93%, mean age 63.3 ± 9.7), who underwent percutaneous peripheral intervention were included retrospectively. The patients were divided into two groups according to the angiographically detected lesions. Those with TASC A-B lesions were included in Group 1, and those with TASC C-D lesions were included in Group 2. TyG index was calculated as formula: ln[fasting TG (mg/dL) × fasting plasma glucose (mg/dL)/2]. RESULTS: There were 40 patients in Group 1 (90.3% men, with a mean age of 63.6 ± 9.3 years) and 31 patients in Group 2 (96.8% men, with a mean age of 62.0 ± 8.6 years). In the majority of patients in both groups, the target vessels are iliac arteries and femoral arteries. In Group 2, platelet count and TyG index were significantly high, according to Group 1. The TyG index was significantly correlated with TASC-II, Rutherford category, HbA1c, and HDL-C. CONCLUSION: In this present study, we showed that the TyG index was an independent predictor of peripheral artery disease complexity, according to TASC-II classification, for the first time in the literature. The Scientific and Technological Research Council of Turkey 2020-08-26 /pmc/articles/PMC7491281/ /pubmed/32718124 http://dx.doi.org/10.3906/sag-2006-180 Text en Copyright © 2020 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
DURAN KARADUMAN, Bilge
AYHAN, Hüseyin
KELEŞ, Telat
BOZKURT, Engin
The triglyceride-glucose index predicts peripheral artery disease complexity
title The triglyceride-glucose index predicts peripheral artery disease complexity
title_full The triglyceride-glucose index predicts peripheral artery disease complexity
title_fullStr The triglyceride-glucose index predicts peripheral artery disease complexity
title_full_unstemmed The triglyceride-glucose index predicts peripheral artery disease complexity
title_short The triglyceride-glucose index predicts peripheral artery disease complexity
title_sort triglyceride-glucose index predicts peripheral artery disease complexity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491281/
https://www.ncbi.nlm.nih.gov/pubmed/32718124
http://dx.doi.org/10.3906/sag-2006-180
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