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Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy
BACKGROUND: Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between vaginal microbiome and pregnant women with penicillin allergy was investigated....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491301/ https://www.ncbi.nlm.nih.gov/pubmed/32944033 http://dx.doi.org/10.1186/s13223-020-00475-5 |
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author | Li, Xiaohua Luo, Jun Nie, Chuan Li, Qingxia Sun, Xiaofeng Li, Hongping Zhang, Yong |
author_facet | Li, Xiaohua Luo, Jun Nie, Chuan Li, Qingxia Sun, Xiaofeng Li, Hongping Zhang, Yong |
author_sort | Li, Xiaohua |
collection | PubMed |
description | BACKGROUND: Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between vaginal microbiome and pregnant women with penicillin allergy was investigated. METHODS: Vaginal samples before labor from 12 pregnant women with penicillin allergy and 15 non-allergic pregnant women were collected. Bacterial community structure of all study subjects and the discrepancies between the two groups were analyzed using 16S rRNA sequencing based on Illumina Hiseq 2500 platform. RESULTS: The abundant phyla among all participants were Firmicutes, Actinobacteria and Bacteroidetes. The predominant genus was Lactobacillus. Compared to non-allergic pregnant women, Actinobacteria, Coriobacteriaceae, Lachnospiraceae, Paraprevotella and Anoxybacillus significantly decreased, whereas Deltaproteobacteria, Peptostreptococcaceae, Enterococcus and Megamonas were more abundant in penicillin allergic women. Additionally, obvious discrepancies were observed in the co-abundance network at the genus level between the two groups. CONCLUSIONS: There were differences in the microbial community structure and composition of reproduction tract between penicillin allergic and non-allergic pregnant women. These shifts may be related to maternal and neonatal health. |
format | Online Article Text |
id | pubmed-7491301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74913012020-09-16 Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy Li, Xiaohua Luo, Jun Nie, Chuan Li, Qingxia Sun, Xiaofeng Li, Hongping Zhang, Yong Allergy Asthma Clin Immunol Research BACKGROUND: Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between vaginal microbiome and pregnant women with penicillin allergy was investigated. METHODS: Vaginal samples before labor from 12 pregnant women with penicillin allergy and 15 non-allergic pregnant women were collected. Bacterial community structure of all study subjects and the discrepancies between the two groups were analyzed using 16S rRNA sequencing based on Illumina Hiseq 2500 platform. RESULTS: The abundant phyla among all participants were Firmicutes, Actinobacteria and Bacteroidetes. The predominant genus was Lactobacillus. Compared to non-allergic pregnant women, Actinobacteria, Coriobacteriaceae, Lachnospiraceae, Paraprevotella and Anoxybacillus significantly decreased, whereas Deltaproteobacteria, Peptostreptococcaceae, Enterococcus and Megamonas were more abundant in penicillin allergic women. Additionally, obvious discrepancies were observed in the co-abundance network at the genus level between the two groups. CONCLUSIONS: There were differences in the microbial community structure and composition of reproduction tract between penicillin allergic and non-allergic pregnant women. These shifts may be related to maternal and neonatal health. BioMed Central 2020-09-09 /pmc/articles/PMC7491301/ /pubmed/32944033 http://dx.doi.org/10.1186/s13223-020-00475-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Li, Xiaohua Luo, Jun Nie, Chuan Li, Qingxia Sun, Xiaofeng Li, Hongping Zhang, Yong Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy |
title | Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy |
title_full | Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy |
title_fullStr | Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy |
title_full_unstemmed | Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy |
title_short | Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy |
title_sort | altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491301/ https://www.ncbi.nlm.nih.gov/pubmed/32944033 http://dx.doi.org/10.1186/s13223-020-00475-5 |
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