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Systemic Immunometabolism: Challenges and Opportunities
Over the past 10 years, the field of immunometabolism made great strides to unveil the crucial role of intracellular metabolism in regulating immune cell function. Emerging insights into how systemic inflammation and metabolism influence each other provide a critical additional dimension on the orga...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491485/ https://www.ncbi.nlm.nih.gov/pubmed/32937151 http://dx.doi.org/10.1016/j.immuni.2020.08.012 |
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author | Lercher, Alexander Baazim, Hatoon Bergthaler, Andreas |
author_facet | Lercher, Alexander Baazim, Hatoon Bergthaler, Andreas |
author_sort | Lercher, Alexander |
collection | PubMed |
description | Over the past 10 years, the field of immunometabolism made great strides to unveil the crucial role of intracellular metabolism in regulating immune cell function. Emerging insights into how systemic inflammation and metabolism influence each other provide a critical additional dimension on the organismal level. Here, we discuss the concept of systemic immunometabolism and review the current understanding of the communication circuits that underlie the reciprocal impact of systemic inflammation and metabolism across organs in inflammatory and infectious diseases, as well as how these mechanisms apply to homeostasis. We present current challenges of systemic immunometabolic research, and in this context, highlight opportunities and put forward ideas to effectively explore organismal physiological complexity in both health and disease. |
format | Online Article Text |
id | pubmed-7491485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74914852020-09-16 Systemic Immunometabolism: Challenges and Opportunities Lercher, Alexander Baazim, Hatoon Bergthaler, Andreas Immunity Review Over the past 10 years, the field of immunometabolism made great strides to unveil the crucial role of intracellular metabolism in regulating immune cell function. Emerging insights into how systemic inflammation and metabolism influence each other provide a critical additional dimension on the organismal level. Here, we discuss the concept of systemic immunometabolism and review the current understanding of the communication circuits that underlie the reciprocal impact of systemic inflammation and metabolism across organs in inflammatory and infectious diseases, as well as how these mechanisms apply to homeostasis. We present current challenges of systemic immunometabolic research, and in this context, highlight opportunities and put forward ideas to effectively explore organismal physiological complexity in both health and disease. Elsevier Inc. 2020-09-15 2020-09-15 /pmc/articles/PMC7491485/ /pubmed/32937151 http://dx.doi.org/10.1016/j.immuni.2020.08.012 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Lercher, Alexander Baazim, Hatoon Bergthaler, Andreas Systemic Immunometabolism: Challenges and Opportunities |
title | Systemic Immunometabolism: Challenges and Opportunities |
title_full | Systemic Immunometabolism: Challenges and Opportunities |
title_fullStr | Systemic Immunometabolism: Challenges and Opportunities |
title_full_unstemmed | Systemic Immunometabolism: Challenges and Opportunities |
title_short | Systemic Immunometabolism: Challenges and Opportunities |
title_sort | systemic immunometabolism: challenges and opportunities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491485/ https://www.ncbi.nlm.nih.gov/pubmed/32937151 http://dx.doi.org/10.1016/j.immuni.2020.08.012 |
work_keys_str_mv | AT lercheralexander systemicimmunometabolismchallengesandopportunities AT baazimhatoon systemicimmunometabolismchallengesandopportunities AT bergthalerandreas systemicimmunometabolismchallengesandopportunities |