Cargando…

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

Mostrar otras versiones (1)

It remains unclear why some patients infected with SARS-CoV-2 readily resolve infection while others develop severe disease. To address this question, we employed a novel assay to interrogate immune-metabolic programs of T cells and myeloid cells in severe and recovered COVID-19 patients. Using this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thompson, Elizabeth A., Cascino, Katherine, Ordonez, Alvaro A., Zhou, Weiqiang, Vaghasia, Ajay, Hamacher-Brady, Anne, Brady, Nathan R., Sun, Im-Hong, Wang, Rulin, Rosenberg, Avi Z., Delannoy, Michael, Rothman, Richard, Fenstermacher, Katherine, Sauer, Lauren, Shaw-Saliba, Kathyrn, Bloch, Evan M., Redd, Andrew D., Tobian, Aaron AR, Horton, Maureen, Smith, Kellie, Pekosz, Andrew, D’Alessio, Franco R., Yegnasubramanian, Srinivasan, Ji, Hongkai, Cox, Andrea L., Powell, Jonathan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491535/ https://www.ncbi.nlm.nih.gov/pubmed/32935120 http://dx.doi.org/10.1101/2020.09.10.20186064

Ejemplares similares

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
por: Thompson, Elizabeth A., et al.
Publicado: (2021)

2019–20 H1N1 clade A5a.1 viruses have better in vitro replication compared with the co-circulating A5a.2 clade
por: Swanson, Nicholas J, et al.
Publicado: (2023)

2019–2020 H1N1 clade A5a.1 viruses have better in vitro fitness compared with the co-circulating A5a.2 clade
por: Swanson, Nicholas J., et al.
Publicado: (2023)

Author Correction: 2019–2020 H1N1 clade A5a.1 viruses have better in vitro fitness compared with the co-circulating A5a.2 clade
por: Swanson, Nicholas J., et al.
Publicado: (2023)

Characteristics of SARS-CoV-2 Seropositivity among Emergency Department Healthcare Workers at a Tertiary Care Center in Baltimore
por: Russell, Anna, et al.
Publicado: (2022)

CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
por: Redd, Andrew D, et al.
Publicado: (2021)

Minimal cross-over between mutations associated with Omicron variant of SARS-CoV-2 and CD8+ T cell epitopes identified in COVID-19 convalescent individuals
por: Redd, Andrew D, et al.
Publicado: (2021)

Facility-based surveillance for influenza and respiratory syncytial virus in rural Zambia
por: Loevinsohn, Gideon, et al.
Publicado: (2021)

The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures
por: Wilson, Jo L., et al.
Publicado: (2023)

Respiratory pathogen diversity and co-infections in rural Zambia
por: Loevinsohn, Gideon, et al.
Publicado: (2020)

Differential Cytokine Signatures of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Influenza Infection Highlight Key Differences in Pathobiology
por: Karaba, Andrew H, et al.
Publicado: (2021)

The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection-Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures
por: Wilson, Jo L., et al.
Publicado: (2023)

Impact of coinfection status and comorbidity on disease severity in adult emergency department patients with influenza B
por: Zapf, Alexander J., et al.
Publicado: (2021)

CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
por: Redd, Andrew D, et al.
Publicado: (2021)

Minimal Crossover between Mutations Associated with Omicron Variant of SARS-CoV-2 and CD8(+) T-Cell Epitopes Identified in COVID-19 Convalescent Individuals
por: Redd, Andrew D., et al.
Publicado: (2022)

Uptake of public health measures and vaccine acceptance during the COVID-19 pandemic in rural Zambia
por: Sutcliffe, Catherine G., et al.
Publicado: (2022)

IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function
por: Casciola-Rosen, Livia, et al.
Publicado: (2022)

Respiratory viruses in rural Zambia during the second year of the COVID-19 pandemic
por: Sutcliffe, Catherine G., et al.
Publicado: (2023)

Differential disease severity and whole-genome sequence analysis for human influenza A/H1N1pdm virus in 2015–2016 influenza season
por: Liu, Hsuan, et al.
Publicado: (2021)

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy
por: Hamacher-Brady, Anne, et al.
Publicado: (2015)

Respiratory viruses in rural Zambia before and during the COVID‐19 pandemic
por: Loevinsohn, Gideon, et al.
Publicado: (2022)

Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children With Acute Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome With Similar Levels of Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 Shedding
por: Peart Akindele, Nadine, et al.
Publicado: (2021)

Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers
por: Heaney, Christopher D., et al.
Publicado: (2021)

LB-18. Broad and Prevalent SARS-CoV-2 CD8+ T Cell Response in Recovered COVID-19 Individuals Demonstrates Kinetics of Early Differentiation
por: Kared, Hassen, et al.
Publicado: (2020)

Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis
por: Choe, Sehyo Charley, et al.
Publicado: (2015)

451. Pre- and Post-implementation Comparison of the Impact of Emergency Department (ED)-Based COVID-19 Point-of-Care Testing on ED Patient Metrics
por: Fenstermacher, Katherine Z J, et al.
Publicado: (2023)

895. Multisite Derivation and Validation of Machine Learning Models to Predict Severe Influenza Outcomes in Emergency Department Patients
por: Hinson, Jeremiah S, et al.
Publicado: (2023)

Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy
por: Hundeshagen, Phillip, et al.
Publicado: (2011)

Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics
por: Börlin, Christoph S, et al.
Publicado: (2014)

Antibody Attributes that Predict the Neutralization and Effector Function of Polyclonal Responses to SARS-CoV-2
por: Natarajan, Harini, et al.
Publicado: (2021)

Comparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers
por: Patel, Eshan U., et al.
Publicado: (2020)

CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entire SARS-CoV-2 proteome and show kinetics of early differentiation
por: Kared, Hassen, et al.
Publicado: (2020)

Heterologous versus homologous boosting elicits qualitatively distinct, BA.5–cross-reactive T cells in transplant recipients
por: Thompson, Elizabeth A., et al.
Publicado: (2023)

Cytokine and Chemokine Levels in Coronavirus Disease 2019 Convalescent Plasma
por: Bonny, Tania S, et al.
Publicado: (2020)

Absence of pathogenic viruses in COVID‐19 convalescent plasma
por: Kandathil, Abraham J., et al.
Publicado: (2022)

Images of Healing
por: Willette, Brady, et al.
Publicado: (2015)

SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy
por: Natarajan, Harini, et al.
Publicado: (2020)

Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells
por: Eling, Nils, et al.
Publicado: (2015)

Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity
por: Dalmasso, Giovanni, et al.
Publicado: (2017)

SARS-CoV-2 mRNA vaccination elicits broad and potent Fc effector functions to VOCs in vulnerable populations
por: Hederman, Andrew P., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_np5f0c4p1044nivkijmotjbl7e