Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

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A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to be defined. Here we engineer the D614G mutation in the SARS-CoV-2 USA-WA1/2020 strain and characterize its effect on viral replica...

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Detalles Bibliográficos
Autores principales: Shi, Pei-Yong, Plante, Jessica, Liu, Yang, Liu, Jianying, Xia, Hongjie, Johnson, Bryan, Lokugamage, Kumari, Zhang, Xianwen, Muruato, Antonio, Zou, Jing, Fontes-Garfias, Camila, Mirchandani, Divya, Scharton, Dionna, Kalveram, Birte, Bilello, John, Ku, Zhiqiang, An, Zhiqiang, Freiberg, Alexander, Menachery, Vineet, Xie, Xuping, Plante, Kenneth, Weaver, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491579/
https://www.ncbi.nlm.nih.gov/pubmed/32935091
http://dx.doi.org/10.21203/rs.3.rs-70482/v1

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