Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis

Baclofen, a muscle relaxant is primarily excreted by the kidneys. We present the case of a 60-year-old male who developed acute delirium, visual hallucinations, and behavioral changes after he took a friend’s prescription of baclofen for pain relief. There was immediate improvement after dialysis, a...

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Autores principales: Riaz, Muhammad Faisal, Andrabi, Suhaib A, Weerasinghe, Anya, Handoo, Maryam, Jain, Sudhanshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491685/
https://www.ncbi.nlm.nih.gov/pubmed/32953296
http://dx.doi.org/10.7759/cureus.9778
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author Riaz, Muhammad Faisal
Andrabi, Suhaib A
Weerasinghe, Anya
Handoo, Maryam
Jain, Sudhanshu
author_facet Riaz, Muhammad Faisal
Andrabi, Suhaib A
Weerasinghe, Anya
Handoo, Maryam
Jain, Sudhanshu
author_sort Riaz, Muhammad Faisal
collection PubMed
description Baclofen, a muscle relaxant is primarily excreted by the kidneys. We present the case of a 60-year-old male who developed acute delirium, visual hallucinations, and behavioral changes after he took a friend’s prescription of baclofen for pain relief. There was immediate improvement after dialysis, and multiple sessions of hemodialysis led to complete resolution of symptoms. A high suspicion for pharmacological causes of delirium is needed in the end stage renal disease (ESRD). Baclofen is known but under recognized cause of acute delirium in ESRD patients. We discuss the pharmacokinetics of baclofen. We suggest reducing dose or preferably avoiding use of baclofen in ESRD patients, especially the elderly.
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spelling pubmed-74916852020-09-17 Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis Riaz, Muhammad Faisal Andrabi, Suhaib A Weerasinghe, Anya Handoo, Maryam Jain, Sudhanshu Cureus Neurology Baclofen, a muscle relaxant is primarily excreted by the kidneys. We present the case of a 60-year-old male who developed acute delirium, visual hallucinations, and behavioral changes after he took a friend’s prescription of baclofen for pain relief. There was immediate improvement after dialysis, and multiple sessions of hemodialysis led to complete resolution of symptoms. A high suspicion for pharmacological causes of delirium is needed in the end stage renal disease (ESRD). Baclofen is known but under recognized cause of acute delirium in ESRD patients. We discuss the pharmacokinetics of baclofen. We suggest reducing dose or preferably avoiding use of baclofen in ESRD patients, especially the elderly. Cureus 2020-08-16 /pmc/articles/PMC7491685/ /pubmed/32953296 http://dx.doi.org/10.7759/cureus.9778 Text en Copyright © 2020, Riaz et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Riaz, Muhammad Faisal
Andrabi, Suhaib A
Weerasinghe, Anya
Handoo, Maryam
Jain, Sudhanshu
Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis
title Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis
title_full Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis
title_fullStr Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis
title_full_unstemmed Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis
title_short Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis
title_sort short-term use of baclofen leading to delirium in a patient with end stage renal disease receiving hemodialysis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491685/
https://www.ncbi.nlm.nih.gov/pubmed/32953296
http://dx.doi.org/10.7759/cureus.9778
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