Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam

This report describes the treatment of Klebsiella pneumoniae carbapenemase (KPC)–3–producing multidrug-resistant K. pneumoniae with ceftazidime/avibactam (CAZ-AVI) in a patient who developed postneurosurgical meningitis and bacteremia. Therapeutic drug monitoring of cerebrospinal fluid and blood sam...

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Autores principales: Yasmin, Mohamad, Hanrahan, Jennifer, Marshall, Steven, Lodise, Thomas P, Chen, Liang, Perez, Federico, Kreiswirth, Barry, Bonomo, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491706/
https://www.ncbi.nlm.nih.gov/pubmed/32964066
http://dx.doi.org/10.1093/ofid/ofaa349
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author Yasmin, Mohamad
Hanrahan, Jennifer
Marshall, Steven
Lodise, Thomas P
Chen, Liang
Perez, Federico
Kreiswirth, Barry
Bonomo, Robert A
author_facet Yasmin, Mohamad
Hanrahan, Jennifer
Marshall, Steven
Lodise, Thomas P
Chen, Liang
Perez, Federico
Kreiswirth, Barry
Bonomo, Robert A
author_sort Yasmin, Mohamad
collection PubMed
description This report describes the treatment of Klebsiella pneumoniae carbapenemase (KPC)–3–producing multidrug-resistant K. pneumoniae with ceftazidime/avibactam (CAZ-AVI) in a patient who developed postneurosurgical meningitis and bacteremia. Therapeutic drug monitoring of cerebrospinal fluid and blood samples demonstrated CAZ-AVI concentration levels 20-fold greater than the minimum inhibitory concentration in the first 60 minutes postinfusion, providing evidence for the utility of CAZ-AVI in treating KPC–Klebsiella pneumoniae central nervous system infections.
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spelling pubmed-74917062020-09-21 Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam Yasmin, Mohamad Hanrahan, Jennifer Marshall, Steven Lodise, Thomas P Chen, Liang Perez, Federico Kreiswirth, Barry Bonomo, Robert A Open Forum Infect Dis Brief Reports This report describes the treatment of Klebsiella pneumoniae carbapenemase (KPC)–3–producing multidrug-resistant K. pneumoniae with ceftazidime/avibactam (CAZ-AVI) in a patient who developed postneurosurgical meningitis and bacteremia. Therapeutic drug monitoring of cerebrospinal fluid and blood samples demonstrated CAZ-AVI concentration levels 20-fold greater than the minimum inhibitory concentration in the first 60 minutes postinfusion, providing evidence for the utility of CAZ-AVI in treating KPC–Klebsiella pneumoniae central nervous system infections. Oxford University Press 2020-08-18 /pmc/articles/PMC7491706/ /pubmed/32964066 http://dx.doi.org/10.1093/ofid/ofaa349 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Yasmin, Mohamad
Hanrahan, Jennifer
Marshall, Steven
Lodise, Thomas P
Chen, Liang
Perez, Federico
Kreiswirth, Barry
Bonomo, Robert A
Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam
title Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam
title_full Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam
title_fullStr Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam
title_full_unstemmed Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam
title_short Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam
title_sort using therapeutic drug monitoring to treat kpc-producing klebsiella pneumoniae central nervous system infection with ceftazidime/avibactam
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491706/
https://www.ncbi.nlm.nih.gov/pubmed/32964066
http://dx.doi.org/10.1093/ofid/ofaa349
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