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Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians

BACKGROUND: Retinoblastoma is the most common primary intraocular malignancy among children. Despite being curable in early stages, majority of the cases in India present in late stages, when outcomes are very poor. OBJECTIVES: The aim of this study was to assess the epidemiological profile, clinica...

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Autores principales: Gupta, Nidhi, Pandey, Awadhesh, Dimri, Kislay, Prinja, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491789/
https://www.ncbi.nlm.nih.gov/pubmed/32984136
http://dx.doi.org/10.4103/jfmpc.jfmpc_265_20
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author Gupta, Nidhi
Pandey, Awadhesh
Dimri, Kislay
Prinja, Shankar
author_facet Gupta, Nidhi
Pandey, Awadhesh
Dimri, Kislay
Prinja, Shankar
author_sort Gupta, Nidhi
collection PubMed
description BACKGROUND: Retinoblastoma is the most common primary intraocular malignancy among children. Despite being curable in early stages, majority of the cases in India present in late stages, when outcomes are very poor. OBJECTIVES: The aim of this study was to assess the epidemiological profile, clinical characteristics, and treatment practices among retinoblastoma patients in north India. MATERIALS AND METHODS: Data on all patients with retinoblastoma, over a 10-year-time period from 2009 to 2018, who were treated in a tertiary care hospital in north India, were assessed. Data were analyzed to describe the demographic characteristics, clinical features in terms of stage at presentation, and management practices in terms of diagnostic investigations and treatment. The statistical significance for difference in percentages was assessed using Fischer's exact test at a 5% significance level. RESULTS: A total of 25 retinoblastoma patients were enlisted, of whom one was excluded as it was adult onset retinoblastoma. The median age at presentation was 3 years, with a male to female ratio of 1:1.4. Bilateral presentation was seen in 16.6% cases. Majority (66.6%) of the patients underwent magnetic resonance imaging of brain and orbit as a part of the diagnostic workup. Intraocular disease was seen in 58.3% patients, whereas 41.6% patients had extraocular disease. Local therapy with vision preservation could be used only in 8.3% patients, whereas 87.5% patients were referred for enucleation. Chemotherapy with combination of vincristine, etoposide, and carboplatin was used extensively both, in neoadjuvant setting (83.3%) and in the adjuvant setting. CONCLUSION: Despite availability of treatment for eye preservation, its utility is limited due to the advanced stage at presentation. Awareness about the disease and its symptoms for early diagnosis, especially with the Mid-Level Health Provider at Health and Wellness Centers, is likely to improve early reporting and treatment and meeting the Vision 2020 goals.
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spelling pubmed-74917892020-09-24 Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians Gupta, Nidhi Pandey, Awadhesh Dimri, Kislay Prinja, Shankar J Family Med Prim Care Original Article BACKGROUND: Retinoblastoma is the most common primary intraocular malignancy among children. Despite being curable in early stages, majority of the cases in India present in late stages, when outcomes are very poor. OBJECTIVES: The aim of this study was to assess the epidemiological profile, clinical characteristics, and treatment practices among retinoblastoma patients in north India. MATERIALS AND METHODS: Data on all patients with retinoblastoma, over a 10-year-time period from 2009 to 2018, who were treated in a tertiary care hospital in north India, were assessed. Data were analyzed to describe the demographic characteristics, clinical features in terms of stage at presentation, and management practices in terms of diagnostic investigations and treatment. The statistical significance for difference in percentages was assessed using Fischer's exact test at a 5% significance level. RESULTS: A total of 25 retinoblastoma patients were enlisted, of whom one was excluded as it was adult onset retinoblastoma. The median age at presentation was 3 years, with a male to female ratio of 1:1.4. Bilateral presentation was seen in 16.6% cases. Majority (66.6%) of the patients underwent magnetic resonance imaging of brain and orbit as a part of the diagnostic workup. Intraocular disease was seen in 58.3% patients, whereas 41.6% patients had extraocular disease. Local therapy with vision preservation could be used only in 8.3% patients, whereas 87.5% patients were referred for enucleation. Chemotherapy with combination of vincristine, etoposide, and carboplatin was used extensively both, in neoadjuvant setting (83.3%) and in the adjuvant setting. CONCLUSION: Despite availability of treatment for eye preservation, its utility is limited due to the advanced stage at presentation. Awareness about the disease and its symptoms for early diagnosis, especially with the Mid-Level Health Provider at Health and Wellness Centers, is likely to improve early reporting and treatment and meeting the Vision 2020 goals. Wolters Kluwer - Medknow 2020-06-30 /pmc/articles/PMC7491789/ /pubmed/32984136 http://dx.doi.org/10.4103/jfmpc.jfmpc_265_20 Text en Copyright: © 2020 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Gupta, Nidhi
Pandey, Awadhesh
Dimri, Kislay
Prinja, Shankar
Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians
title Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians
title_full Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians
title_fullStr Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians
title_full_unstemmed Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians
title_short Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians
title_sort epidemiological profile of retinoblastoma in north india: implications for primary care and family physicians
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491789/
https://www.ncbi.nlm.nih.gov/pubmed/32984136
http://dx.doi.org/10.4103/jfmpc.jfmpc_265_20
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