Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon

OBJECTIVE. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. METHODS. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará,...

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Autores principales: de Oliveira, Consuelo S, de Matos, Haroldo José, Ramos, Francisco Luzio de Paula, Pinto, Ana Yece das N, Graim, Priscila Nathyelly dos S, Guimarães, Vivianne de Paula R, Gomes, Luna Thaís S, Serra, Emilene M. F, Cruz, Ana Cecília, Leal, Alessandra, Henriques, Daniele F., Lima, Juliana A., Anjos, Maura V., Pinto, Eliana V., de Souza, Alana W., Vasconcelos, Pedro Fernando da C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Organización Panamericana de la Salud 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491861/
https://www.ncbi.nlm.nih.gov/pubmed/32952536
http://dx.doi.org/10.26633/RPSP.2020.116
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author de Oliveira, Consuelo S
de Matos, Haroldo José
Ramos, Francisco Luzio de Paula
Pinto, Ana Yece das N
Graim, Priscila Nathyelly dos S
Guimarães, Vivianne de Paula R
Gomes, Luna Thaís S
Serra, Emilene M. F
Cruz, Ana Cecília
Leal, Alessandra
Henriques, Daniele F.
Lima, Juliana A.
Anjos, Maura V.
Pinto, Eliana V.
de Souza, Alana W.
Vasconcelos, Pedro Fernando da C.
author_facet de Oliveira, Consuelo S
de Matos, Haroldo José
Ramos, Francisco Luzio de Paula
Pinto, Ana Yece das N
Graim, Priscila Nathyelly dos S
Guimarães, Vivianne de Paula R
Gomes, Luna Thaís S
Serra, Emilene M. F
Cruz, Ana Cecília
Leal, Alessandra
Henriques, Daniele F.
Lima, Juliana A.
Anjos, Maura V.
Pinto, Eliana V.
de Souza, Alana W.
Vasconcelos, Pedro Fernando da C.
author_sort de Oliveira, Consuelo S
collection PubMed
description OBJECTIVE. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. METHODS. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará, Brazil, from October 2015 to December 2017. RESULTS. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation. CONCLUSIONS. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection.
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spelling pubmed-74918612020-09-17 Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon de Oliveira, Consuelo S de Matos, Haroldo José Ramos, Francisco Luzio de Paula Pinto, Ana Yece das N Graim, Priscila Nathyelly dos S Guimarães, Vivianne de Paula R Gomes, Luna Thaís S Serra, Emilene M. F Cruz, Ana Cecília Leal, Alessandra Henriques, Daniele F. Lima, Juliana A. Anjos, Maura V. Pinto, Eliana V. de Souza, Alana W. Vasconcelos, Pedro Fernando da C. Rev Panam Salud Publica Original Research OBJECTIVE. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. METHODS. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará, Brazil, from October 2015 to December 2017. RESULTS. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation. CONCLUSIONS. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection. Organización Panamericana de la Salud 2020-09-16 /pmc/articles/PMC7491861/ /pubmed/32952536 http://dx.doi.org/10.26633/RPSP.2020.116 Text en https://creativecommons.org/licenses/by-nc-nd/3.0/igo/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 IGO License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. No modifications or commercial use of this article are permitted. In any reproduction of this article there should not be any suggestion that PAHO or this article endorse any specific organization or products. The use of the PAHO logo is not permitted. This notice should be preserved along with the article’s original URL.
spellingShingle Original Research
de Oliveira, Consuelo S
de Matos, Haroldo José
Ramos, Francisco Luzio de Paula
Pinto, Ana Yece das N
Graim, Priscila Nathyelly dos S
Guimarães, Vivianne de Paula R
Gomes, Luna Thaís S
Serra, Emilene M. F
Cruz, Ana Cecília
Leal, Alessandra
Henriques, Daniele F.
Lima, Juliana A.
Anjos, Maura V.
Pinto, Eliana V.
de Souza, Alana W.
Vasconcelos, Pedro Fernando da C.
Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
title Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
title_full Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
title_fullStr Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
title_full_unstemmed Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
title_short Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
title_sort risk of zika virus-associated birth defects in congenital confirmed cases in the brazilian amazon
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491861/
https://www.ncbi.nlm.nih.gov/pubmed/32952536
http://dx.doi.org/10.26633/RPSP.2020.116
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