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Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis

INTRODUCTION. Bartonella species are increasingly recognized as agents of culture-negative endocarditis. However, to date, almost all human cases have been associated with two members of the genus, Bartonella henselae and Bartonella quintana. B. henselae infections are zoonotic, with domestic cats s...

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Autores principales: Logan, Julie M. J., Hall, Jessica L., Chalker, Vicki J., O’Connell, Brian, Birtles, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491929/
https://www.ncbi.nlm.nih.gov/pubmed/32974498
http://dx.doi.org/10.1099/acmi.0.000064
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author Logan, Julie M. J.
Hall, Jessica L.
Chalker, Vicki J.
O’Connell, Brian
Birtles, Richard J.
author_facet Logan, Julie M. J.
Hall, Jessica L.
Chalker, Vicki J.
O’Connell, Brian
Birtles, Richard J.
author_sort Logan, Julie M. J.
collection PubMed
description INTRODUCTION. Bartonella species are increasingly recognized as agents of culture-negative endocarditis. However, to date, almost all human cases have been associated with two members of the genus, Bartonella henselae and Bartonella quintana. B. henselae infections are zoonotic, with domestic cats serving as reservoir hosts for the pathogen. Bartonella clarridgeiae also exploits cats as reservoir hosts, but its zoonotic potential is far less established. CASE PRESENTATION. A 34-year-old male presented with palpitations after a history of aortic incompetence. During surgery for an aortic valve replacement, two vegetations were found on the aortic valve. PCR analysis of the vegetation demonstrated the presence of Bartonella species and so the patient was treated post-operatively with ceftriaxone and doxycycline, making a good recovery. Further PCR-based analysis of the patient’s aortic vegetation confirmed the presence of B. clarridgeiae . CONCLUSION. This report expands the number of Bartonella species associated with endocarditis and provides clear evidence that B. clarridgeiae should be considered a zoonotic pathogen.
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spelling pubmed-74919292020-09-23 Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis Logan, Julie M. J. Hall, Jessica L. Chalker, Vicki J. O’Connell, Brian Birtles, Richard J. Access Microbiol Case Report INTRODUCTION. Bartonella species are increasingly recognized as agents of culture-negative endocarditis. However, to date, almost all human cases have been associated with two members of the genus, Bartonella henselae and Bartonella quintana. B. henselae infections are zoonotic, with domestic cats serving as reservoir hosts for the pathogen. Bartonella clarridgeiae also exploits cats as reservoir hosts, but its zoonotic potential is far less established. CASE PRESENTATION. A 34-year-old male presented with palpitations after a history of aortic incompetence. During surgery for an aortic valve replacement, two vegetations were found on the aortic valve. PCR analysis of the vegetation demonstrated the presence of Bartonella species and so the patient was treated post-operatively with ceftriaxone and doxycycline, making a good recovery. Further PCR-based analysis of the patient’s aortic vegetation confirmed the presence of B. clarridgeiae . CONCLUSION. This report expands the number of Bartonella species associated with endocarditis and provides clear evidence that B. clarridgeiae should be considered a zoonotic pathogen. Microbiology Society 2019-10-10 /pmc/articles/PMC7491929/ /pubmed/32974498 http://dx.doi.org/10.1099/acmi.0.000064 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License.
spellingShingle Case Report
Logan, Julie M. J.
Hall, Jessica L.
Chalker, Vicki J.
O’Connell, Brian
Birtles, Richard J.
Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis
title Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis
title_full Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis
title_fullStr Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis
title_full_unstemmed Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis
title_short Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis
title_sort bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491929/
https://www.ncbi.nlm.nih.gov/pubmed/32974498
http://dx.doi.org/10.1099/acmi.0.000064
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