Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis ; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis . We...

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Detalles Bibliográficos
Autores principales: Morbidoni, Héctor R., de la Iglesia, Agustina I., Figueroa, Virginia, Di Capua, Cecilia, Ioerger, Thomas R., Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491931/
https://www.ncbi.nlm.nih.gov/pubmed/32974504
http://dx.doi.org/10.1099/acmi.0.000070
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author Morbidoni, Héctor R.
de la Iglesia, Agustina I.
Figueroa, Virginia
Di Capua, Cecilia
Ioerger, Thomas R.
Parish, Tanya
author_facet Morbidoni, Héctor R.
de la Iglesia, Agustina I.
Figueroa, Virginia
Di Capua, Cecilia
Ioerger, Thomas R.
Parish, Tanya
author_sort Morbidoni, Héctor R.
collection PubMed
description Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis ; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis . We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.
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spelling pubmed-74919312020-09-23 Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis Morbidoni, Héctor R. de la Iglesia, Agustina I. Figueroa, Virginia Di Capua, Cecilia Ioerger, Thomas R. Parish, Tanya Access Microbiol Short Communication Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis ; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis . We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein. Microbiology Society 2019-10-29 /pmc/articles/PMC7491931/ /pubmed/32974504 http://dx.doi.org/10.1099/acmi.0.000070 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License.
spellingShingle Short Communication
Morbidoni, Héctor R.
de la Iglesia, Agustina I.
Figueroa, Virginia
Di Capua, Cecilia
Ioerger, Thomas R.
Parish, Tanya
Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_full Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_fullStr Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_full_unstemmed Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_short Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_sort mutations in the anti-sigma h factor rsha confer resistance to econazole and clotrimazole in mycobacterium smegmatis
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491931/
https://www.ncbi.nlm.nih.gov/pubmed/32974504
http://dx.doi.org/10.1099/acmi.0.000070
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