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Neurological reasons for consultation and hospitalization during the COVID-19 pandemic

BACKGROUND: COVID-19 disease affects the nervous system and led to an increase in neurological consults for patients at admission and through the period of hospitalization during the peak of the pandemic. METHODS: Patients with clinical and laboratory diagnosis of COVID-19 that required a neurologic...

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Autores principales: García-Moncó, Juan Carlos, Cabrera-Muras, Antonio, Collía-Fernández, Alejandra, Erburu-Iriarte, Markel, Rodrigo-Armenteros, Patricia, Oyarzun-Irazu, Iñigo, Martínez-Condor, Daniel, Bilbao-González, Amaia, Carmona-Abellán, Mar, Caballero-Romero, Ivan, Gómez-Beldarrain, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491981/
https://www.ncbi.nlm.nih.gov/pubmed/32935157
http://dx.doi.org/10.1007/s10072-020-04714-w
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author García-Moncó, Juan Carlos
Cabrera-Muras, Antonio
Collía-Fernández, Alejandra
Erburu-Iriarte, Markel
Rodrigo-Armenteros, Patricia
Oyarzun-Irazu, Iñigo
Martínez-Condor, Daniel
Bilbao-González, Amaia
Carmona-Abellán, Mar
Caballero-Romero, Ivan
Gómez-Beldarrain, Marian
author_facet García-Moncó, Juan Carlos
Cabrera-Muras, Antonio
Collía-Fernández, Alejandra
Erburu-Iriarte, Markel
Rodrigo-Armenteros, Patricia
Oyarzun-Irazu, Iñigo
Martínez-Condor, Daniel
Bilbao-González, Amaia
Carmona-Abellán, Mar
Caballero-Romero, Ivan
Gómez-Beldarrain, Marian
author_sort García-Moncó, Juan Carlos
collection PubMed
description BACKGROUND: COVID-19 disease affects the nervous system and led to an increase in neurological consults for patients at admission and through the period of hospitalization during the peak of the pandemic. METHODS: Patients with clinical and laboratory diagnosis of COVID-19 that required a neurologic consultation or those who presented with neurological problems on admission that led to a diagnosis of SARS-CoV-2 infection during a 2-month period at the peak of the pandemic were included in this study. Demographic and clinical variables were analyzed. RESULTS: Thirty-five patients were included. The presenting neurologic manifestations on admission led to the diagnosis of COVID-19 in 14 patients (40%). The most common reasons for consultation during the hospitalization period were stroke (11), encephalopathy (7), seizures (6), and neuropathies (5) followed by a miscellaneous of syncope (2), migraine (1), anosmia (1), critical illness myopathy (1), and exacerbation of residual dysarthria (1). The most common neurological disturbances were associated with severe disease except for neuropathies. Patients with encephalopathies and seizures had markedly increased D-dimer and ferritin values, even higher than stroke patients. RT-PCR was performed in 8 CSF samples and was negative in all of them. CONCLUSION: Neurological disturbances represent a significant and severe burden in COVID-19 patients, and they can be the presenting condition that leads to the diagnosis of the viral infection in a high percentage of patients. Evidence of direct viral mechanisms was scarce, but the pathogenesis of the diverse manifestations remains enigmatic.
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spelling pubmed-74919812020-09-16 Neurological reasons for consultation and hospitalization during the COVID-19 pandemic García-Moncó, Juan Carlos Cabrera-Muras, Antonio Collía-Fernández, Alejandra Erburu-Iriarte, Markel Rodrigo-Armenteros, Patricia Oyarzun-Irazu, Iñigo Martínez-Condor, Daniel Bilbao-González, Amaia Carmona-Abellán, Mar Caballero-Romero, Ivan Gómez-Beldarrain, Marian Neurol Sci Covid-19 BACKGROUND: COVID-19 disease affects the nervous system and led to an increase in neurological consults for patients at admission and through the period of hospitalization during the peak of the pandemic. METHODS: Patients with clinical and laboratory diagnosis of COVID-19 that required a neurologic consultation or those who presented with neurological problems on admission that led to a diagnosis of SARS-CoV-2 infection during a 2-month period at the peak of the pandemic were included in this study. Demographic and clinical variables were analyzed. RESULTS: Thirty-five patients were included. The presenting neurologic manifestations on admission led to the diagnosis of COVID-19 in 14 patients (40%). The most common reasons for consultation during the hospitalization period were stroke (11), encephalopathy (7), seizures (6), and neuropathies (5) followed by a miscellaneous of syncope (2), migraine (1), anosmia (1), critical illness myopathy (1), and exacerbation of residual dysarthria (1). The most common neurological disturbances were associated with severe disease except for neuropathies. Patients with encephalopathies and seizures had markedly increased D-dimer and ferritin values, even higher than stroke patients. RT-PCR was performed in 8 CSF samples and was negative in all of them. CONCLUSION: Neurological disturbances represent a significant and severe burden in COVID-19 patients, and they can be the presenting condition that leads to the diagnosis of the viral infection in a high percentage of patients. Evidence of direct viral mechanisms was scarce, but the pathogenesis of the diverse manifestations remains enigmatic. Springer International Publishing 2020-09-15 2020 /pmc/articles/PMC7491981/ /pubmed/32935157 http://dx.doi.org/10.1007/s10072-020-04714-w Text en © Fondazione Società Italiana di Neurologia 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Covid-19
García-Moncó, Juan Carlos
Cabrera-Muras, Antonio
Collía-Fernández, Alejandra
Erburu-Iriarte, Markel
Rodrigo-Armenteros, Patricia
Oyarzun-Irazu, Iñigo
Martínez-Condor, Daniel
Bilbao-González, Amaia
Carmona-Abellán, Mar
Caballero-Romero, Ivan
Gómez-Beldarrain, Marian
Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
title Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
title_full Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
title_fullStr Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
title_full_unstemmed Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
title_short Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
title_sort neurological reasons for consultation and hospitalization during the covid-19 pandemic
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491981/
https://www.ncbi.nlm.nih.gov/pubmed/32935157
http://dx.doi.org/10.1007/s10072-020-04714-w
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