Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin

We herein report a 64-year-old man who was treated with pembrolizumab for relapsed Hodgkin lymphoma. After the third administration of pembrolizumab, he showed acute anemia with a positive direct anti-globulin test. Because of the markedly erythroid hypoplasia, he was diagnosed with pure red cell ap...

Descripción completa

Detalles Bibliográficos
Autores principales: Isoda, Atsushi, Miyazawa, Yuri, Tahara, Kenichi, Mihara, Masahiro, Saito, Akio, Matsumoto, Morio, Sawamura, Morio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492113/
https://www.ncbi.nlm.nih.gov/pubmed/32389947
http://dx.doi.org/10.2169/internalmedicine.4467-20
_version_ 1783582321265344512
author Isoda, Atsushi
Miyazawa, Yuri
Tahara, Kenichi
Mihara, Masahiro
Saito, Akio
Matsumoto, Morio
Sawamura, Morio
author_facet Isoda, Atsushi
Miyazawa, Yuri
Tahara, Kenichi
Mihara, Masahiro
Saito, Akio
Matsumoto, Morio
Sawamura, Morio
author_sort Isoda, Atsushi
collection PubMed
description We herein report a 64-year-old man who was treated with pembrolizumab for relapsed Hodgkin lymphoma. After the third administration of pembrolizumab, he showed acute anemia with a positive direct anti-globulin test. Because of the markedly erythroid hypoplasia, he was diagnosed with pure red cell aplasia (PRCA) caused by pembrolizumab. He was initially treated with prednisolone, but the reticulocytes decreased after tapering prednisolone. He then received high-dose intravenous immunoglobulin (IVIG) with prednisolone, and PRCA was successfully treated. Although the pathogenesis of PRCA caused by immune checkpoint inhibitors (CPIs) remains unclear, IVIG treatment may be effective for some steroid-refractory CPI-induced PRCA cases.
format Online
Article
Text
id pubmed-7492113
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-74921132020-09-23 Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin Isoda, Atsushi Miyazawa, Yuri Tahara, Kenichi Mihara, Masahiro Saito, Akio Matsumoto, Morio Sawamura, Morio Intern Med Case Report We herein report a 64-year-old man who was treated with pembrolizumab for relapsed Hodgkin lymphoma. After the third administration of pembrolizumab, he showed acute anemia with a positive direct anti-globulin test. Because of the markedly erythroid hypoplasia, he was diagnosed with pure red cell aplasia (PRCA) caused by pembrolizumab. He was initially treated with prednisolone, but the reticulocytes decreased after tapering prednisolone. He then received high-dose intravenous immunoglobulin (IVIG) with prednisolone, and PRCA was successfully treated. Although the pathogenesis of PRCA caused by immune checkpoint inhibitors (CPIs) remains unclear, IVIG treatment may be effective for some steroid-refractory CPI-induced PRCA cases. The Japanese Society of Internal Medicine 2020-05-08 2020-08-15 /pmc/articles/PMC7492113/ /pubmed/32389947 http://dx.doi.org/10.2169/internalmedicine.4467-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Isoda, Atsushi
Miyazawa, Yuri
Tahara, Kenichi
Mihara, Masahiro
Saito, Akio
Matsumoto, Morio
Sawamura, Morio
Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin
title Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin
title_full Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin
title_fullStr Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin
title_full_unstemmed Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin
title_short Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin
title_sort pembrolizumab-induced pure red cell aplasia successfully treated with intravenous immunoglobulin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492113/
https://www.ncbi.nlm.nih.gov/pubmed/32389947
http://dx.doi.org/10.2169/internalmedicine.4467-20
work_keys_str_mv AT isodaatsushi pembrolizumabinducedpureredcellaplasiasuccessfullytreatedwithintravenousimmunoglobulin
AT miyazawayuri pembrolizumabinducedpureredcellaplasiasuccessfullytreatedwithintravenousimmunoglobulin
AT taharakenichi pembrolizumabinducedpureredcellaplasiasuccessfullytreatedwithintravenousimmunoglobulin
AT miharamasahiro pembrolizumabinducedpureredcellaplasiasuccessfullytreatedwithintravenousimmunoglobulin
AT saitoakio pembrolizumabinducedpureredcellaplasiasuccessfullytreatedwithintravenousimmunoglobulin
AT matsumotomorio pembrolizumabinducedpureredcellaplasiasuccessfullytreatedwithintravenousimmunoglobulin
AT sawamuramorio pembrolizumabinducedpureredcellaplasiasuccessfullytreatedwithintravenousimmunoglobulin

Ejemplares similares