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Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura

A 70-year-old woman was hospitalized for exacerbation of chronic idiopathic thrombocytopenic purpura (ITP) and disseminated intravascular coagulation (DIC) from old aortic dissection. Initially, we increased the dose of prednisolone for ITP. However, her bleeding tendency caused by DIC worsened desp...

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Autores principales: Uemura, Shun, Kobayashi, Hironori, Seki, Yoshinobu, Okoshi, Yuki, Sone, Hirohito, Nomoto, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492122/
https://www.ncbi.nlm.nih.gov/pubmed/32389942
http://dx.doi.org/10.2169/internalmedicine.4255-19
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author Uemura, Shun
Kobayashi, Hironori
Seki, Yoshinobu
Okoshi, Yuki
Sone, Hirohito
Nomoto, Nobuhiko
author_facet Uemura, Shun
Kobayashi, Hironori
Seki, Yoshinobu
Okoshi, Yuki
Sone, Hirohito
Nomoto, Nobuhiko
author_sort Uemura, Shun
collection PubMed
description A 70-year-old woman was hospitalized for exacerbation of chronic idiopathic thrombocytopenic purpura (ITP) and disseminated intravascular coagulation (DIC) from old aortic dissection. Initially, we increased the dose of prednisolone for ITP. However, her bleeding tendency caused by DIC worsened despite the rapid recovery of her platelet count, and the required amount of fresh-frozen plasma for transfusion increased. The administration of edoxaban for atrial fibrillation led to the marked improvement of her DIC status without serious adverse events. This case suggests that a direct oral anticoagulant may be an effective treatment for DIC caused by aortic dissection.
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spelling pubmed-74921222020-09-23 Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura Uemura, Shun Kobayashi, Hironori Seki, Yoshinobu Okoshi, Yuki Sone, Hirohito Nomoto, Nobuhiko Intern Med Case Report A 70-year-old woman was hospitalized for exacerbation of chronic idiopathic thrombocytopenic purpura (ITP) and disseminated intravascular coagulation (DIC) from old aortic dissection. Initially, we increased the dose of prednisolone for ITP. However, her bleeding tendency caused by DIC worsened despite the rapid recovery of her platelet count, and the required amount of fresh-frozen plasma for transfusion increased. The administration of edoxaban for atrial fibrillation led to the marked improvement of her DIC status without serious adverse events. This case suggests that a direct oral anticoagulant may be an effective treatment for DIC caused by aortic dissection. The Japanese Society of Internal Medicine 2020-05-08 2020-08-15 /pmc/articles/PMC7492122/ /pubmed/32389942 http://dx.doi.org/10.2169/internalmedicine.4255-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Uemura, Shun
Kobayashi, Hironori
Seki, Yoshinobu
Okoshi, Yuki
Sone, Hirohito
Nomoto, Nobuhiko
Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura
title Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura
title_full Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura
title_fullStr Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura
title_full_unstemmed Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura
title_short Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura
title_sort successful treatment with edoxaban for disseminated intravascular coagulation in a case of aortic dissection complicated with immune thrombocytopenic purpura
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492122/
https://www.ncbi.nlm.nih.gov/pubmed/32389942
http://dx.doi.org/10.2169/internalmedicine.4255-19
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