Chloroquine against malaria, cancers and viral diseases

Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites. Repurposing CQ is an emerging strategy for new indi...

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Autores principales: Zhou, Wenmin, Wang, Hui, Yang, Yuqi, Chen, Zhe-Sheng, Zou, Chang, Zhang, Jianye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492153/
https://www.ncbi.nlm.nih.gov/pubmed/32947043
http://dx.doi.org/10.1016/j.drudis.2020.09.010
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author Zhou, Wenmin
Wang, Hui
Yang, Yuqi
Chen, Zhe-Sheng
Zou, Chang
Zhang, Jianye
author_facet Zhou, Wenmin
Wang, Hui
Yang, Yuqi
Chen, Zhe-Sheng
Zou, Chang
Zhang, Jianye
author_sort Zhou, Wenmin
collection PubMed
description Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites. Repurposing CQ is an emerging strategy for new indications. Given the inhibition of autophagy and its immunomodulatory action, CQ shows positive efficacy against cancer and viral diseases, including Coronavirus 2019 (COVID-19). Here, we review the underlying mechanisms behind the antimalarial, anticancer and antiviral effects of CQ. We also discuss the clinical evidence for the use of CQ and hydroxychloroquine (HCQ) against COVID-19.
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spelling pubmed-74921532020-09-16 Chloroquine against malaria, cancers and viral diseases Zhou, Wenmin Wang, Hui Yang, Yuqi Chen, Zhe-Sheng Zou, Chang Zhang, Jianye Drug Discov Today Review Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites. Repurposing CQ is an emerging strategy for new indications. Given the inhibition of autophagy and its immunomodulatory action, CQ shows positive efficacy against cancer and viral diseases, including Coronavirus 2019 (COVID-19). Here, we review the underlying mechanisms behind the antimalarial, anticancer and antiviral effects of CQ. We also discuss the clinical evidence for the use of CQ and hydroxychloroquine (HCQ) against COVID-19. Elsevier Ltd. 2020-11 2020-09-16 /pmc/articles/PMC7492153/ /pubmed/32947043 http://dx.doi.org/10.1016/j.drudis.2020.09.010 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Zhou, Wenmin
Wang, Hui
Yang, Yuqi
Chen, Zhe-Sheng
Zou, Chang
Zhang, Jianye
Chloroquine against malaria, cancers and viral diseases
title Chloroquine against malaria, cancers and viral diseases
title_full Chloroquine against malaria, cancers and viral diseases
title_fullStr Chloroquine against malaria, cancers and viral diseases
title_full_unstemmed Chloroquine against malaria, cancers and viral diseases
title_short Chloroquine against malaria, cancers and viral diseases
title_sort chloroquine against malaria, cancers and viral diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492153/
https://www.ncbi.nlm.nih.gov/pubmed/32947043
http://dx.doi.org/10.1016/j.drudis.2020.09.010
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