Staufen 1 amplifies proapoptotic activation of the unfolded protein response

Staufen-1 (STAU1) is an RNA-binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (PSEN1), microtubule-associated protein tau (MAPT), huntingtin (HTT), TAR DNA-binding protein-43 gene (TARDBP), or C9orf72. We...

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Detalles Bibliográficos
Autores principales: Gandelman, Mandi, Dansithong, Warunee, Figueroa, Karla P., Paul, Sharan, Scoles, Daniel R., Pulst, Stefan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492261/
https://www.ncbi.nlm.nih.gov/pubmed/32415281
http://dx.doi.org/10.1038/s41418-020-0553-9

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