A shared genetic contribution to breast cancer and schizophrenia

An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophreni...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Donghao, Song, Jie, Lu, Yi, Fall, Katja, Chen, Xu, Fang, Fang, Landén, Mikael, Hultman, Christina M., Czene, Kamila, Sullivan, Patrick, Tamimi, Rulla M., Valdimarsdóttir, Unnur A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492262/
https://www.ncbi.nlm.nih.gov/pubmed/32934226
http://dx.doi.org/10.1038/s41467-020-18492-8
_version_ 1783582354411880448
author Lu, Donghao
Song, Jie
Lu, Yi
Fall, Katja
Chen, Xu
Fang, Fang
Landén, Mikael
Hultman, Christina M.
Czene, Kamila
Sullivan, Patrick
Tamimi, Rulla M.
Valdimarsdóttir, Unnur A.
author_facet Lu, Donghao
Song, Jie
Lu, Yi
Fall, Katja
Chen, Xu
Fang, Fang
Landén, Mikael
Hultman, Christina M.
Czene, Kamila
Sullivan, Patrick
Tamimi, Rulla M.
Valdimarsdóttir, Unnur A.
author_sort Lu, Donghao
collection PubMed
description An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09–0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.
format Online
Article
Text
id pubmed-7492262
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-74922622020-10-01 A shared genetic contribution to breast cancer and schizophrenia Lu, Donghao Song, Jie Lu, Yi Fall, Katja Chen, Xu Fang, Fang Landén, Mikael Hultman, Christina M. Czene, Kamila Sullivan, Patrick Tamimi, Rulla M. Valdimarsdóttir, Unnur A. Nat Commun Article An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09–0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms. Nature Publishing Group UK 2020-09-15 /pmc/articles/PMC7492262/ /pubmed/32934226 http://dx.doi.org/10.1038/s41467-020-18492-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lu, Donghao
Song, Jie
Lu, Yi
Fall, Katja
Chen, Xu
Fang, Fang
Landén, Mikael
Hultman, Christina M.
Czene, Kamila
Sullivan, Patrick
Tamimi, Rulla M.
Valdimarsdóttir, Unnur A.
A shared genetic contribution to breast cancer and schizophrenia
title A shared genetic contribution to breast cancer and schizophrenia
title_full A shared genetic contribution to breast cancer and schizophrenia
title_fullStr A shared genetic contribution to breast cancer and schizophrenia
title_full_unstemmed A shared genetic contribution to breast cancer and schizophrenia
title_short A shared genetic contribution to breast cancer and schizophrenia
title_sort shared genetic contribution to breast cancer and schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492262/
https://www.ncbi.nlm.nih.gov/pubmed/32934226
http://dx.doi.org/10.1038/s41467-020-18492-8
work_keys_str_mv AT ludonghao asharedgeneticcontributiontobreastcancerandschizophrenia
AT songjie asharedgeneticcontributiontobreastcancerandschizophrenia
AT luyi asharedgeneticcontributiontobreastcancerandschizophrenia
AT fallkatja asharedgeneticcontributiontobreastcancerandschizophrenia
AT chenxu asharedgeneticcontributiontobreastcancerandschizophrenia
AT fangfang asharedgeneticcontributiontobreastcancerandschizophrenia
AT landenmikael asharedgeneticcontributiontobreastcancerandschizophrenia
AT hultmanchristinam asharedgeneticcontributiontobreastcancerandschizophrenia
AT czenekamila asharedgeneticcontributiontobreastcancerandschizophrenia
AT sullivanpatrick asharedgeneticcontributiontobreastcancerandschizophrenia
AT tamimirullam asharedgeneticcontributiontobreastcancerandschizophrenia
AT valdimarsdottirunnura asharedgeneticcontributiontobreastcancerandschizophrenia
AT ludonghao sharedgeneticcontributiontobreastcancerandschizophrenia
AT songjie sharedgeneticcontributiontobreastcancerandschizophrenia
AT luyi sharedgeneticcontributiontobreastcancerandschizophrenia
AT fallkatja sharedgeneticcontributiontobreastcancerandschizophrenia
AT chenxu sharedgeneticcontributiontobreastcancerandschizophrenia
AT fangfang sharedgeneticcontributiontobreastcancerandschizophrenia
AT landenmikael sharedgeneticcontributiontobreastcancerandschizophrenia
AT hultmanchristinam sharedgeneticcontributiontobreastcancerandschizophrenia
AT czenekamila sharedgeneticcontributiontobreastcancerandschizophrenia
AT sullivanpatrick sharedgeneticcontributiontobreastcancerandschizophrenia
AT tamimirullam sharedgeneticcontributiontobreastcancerandschizophrenia
AT valdimarsdottirunnura sharedgeneticcontributiontobreastcancerandschizophrenia

Ejemplares similares