Cargando…

Enhanced Anticancer Effect of a Combination of S-adenosylmethionine (SAM) and Immune Checkpoint Inhibitor (ICPi) in a Syngeneic Mouse Model of Advanced Melanoma

Immune checkpoint inhibitors (ICPi) targeting the PD-1/PD-L1 pathway have shown marked success in patients with advanced melanoma. However, 60–70% of patients fail to respond, warranting a therapeutic intervention that could increase response rates. We and others have shown that S-adenosylmethionine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mehdi, Ali, Attias, Mikhael, Mahmood, Niaz, Arakelian, Ani, Mihalcioiu, Catalin, Piccirillo, Ciriaco A., Szyf, Moshe, Rabbani, Shafaat Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492272/ https://www.ncbi.nlm.nih.gov/pubmed/32983966 http://dx.doi.org/10.3389/fonc.2020.01361

Ejemplares similares

Co-Targeting Luminal B Breast Cancer with S-Adenosylmethionine and Immune Checkpoint Inhibitor Reduces Primary Tumor Growth and Progression, and Metastasis to Lungs and Bone
por: Mehdi, Ali, et al.
Publicado: (2022)

S‐adenosylmethionine in combination with decitabine shows enhanced anti‐cancer effects in repressing breast cancer growth and metastasis
por: Mahmood, Niaz, et al.
Publicado: (2020)

Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications
por: Mahmood, Niaz, et al.
Publicado: (2017)

An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis
por: Mahmood, Niaz, et al.
Publicado: (2020)

S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas
por: Mehdi, A., et al.
Publicado: (2023)

DNA methylation signatures of breast cancer in peripheral T-cells
por: Parashar, Surabhi, et al.
Publicado: (2018)

S-adenosylmethionine blocks osteosarcoma cells proliferation and invasion in vitro and tumor metastasis in vivo: therapeutic and diagnostic clinical applications
por: Parashar, Surabhi, et al.
Publicado: (2015)

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications
por: Mahmood, Niaz, et al.
Publicado: (2018)

DNA methylation signatures of Prostate Cancer in peripheral T-cells
por: Mehdi, Ali, et al.
Publicado: (2020)

uPAR antibody (huATN-658) and Zometa reduce breast cancer growth and skeletal lesions
por: Mahmood, Niaz, et al.
Publicado: (2020)

LRP5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis in vitro and in vivo
por: Rabbani, Shafaat A, et al.
Publicado: (2013)

A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness
por: Cheishvili, David, et al.
Publicado: (2015)

Paramagnetic Intermediates Generated by Radical S-Adenosylmethionine (SAM) Enzymes
por: Stich, Troy A., et al.
Publicado: (2014)

S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS
por: Shippy, R Andrew, et al.
Publicado: (2004)

DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications
por: Mahmood, Niaz, et al.
Publicado: (2019)

Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
por: Mahmood, Niaz, et al.
Publicado: (2021)

S-Adenosylmethionine (SAM)-Dependent Methyltransferase MftM is Responsible for Methylation of the Redox Cofactor Mycofactocin
por: Ellerhorst, Mark, et al.
Publicado: (2022)

S-adenosyl-methionine (SAM) alters the transcriptome and methylome and specifically blocks growth and invasiveness of liver cancer cells
por: Wang, Yan, et al.
Publicado: (2017)

A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion
por: Dai, Meiou, et al.
Publicado: (2012)

Erratum to: A novel function for p21 Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion
por: Dai, Meiou, et al.
Publicado: (2017)

An Immune-Clinical Prognostic Index (ICPI) for Patients With De Novo Follicular Lymphoma Treated With R-CHOP/CHOP Chemotherapy
por: Lu, Yaxiao, et al.
Publicado: (2021)

Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition
por: Lax, Elad, et al.
Publicado: (2023)

SUN-LB024 Elevation in Morning Glucose Level May Be a Signal for the Development of Immune Checkpoint Inhibitor (ICPi) Induced Autoimmune Diabetes Insulin
por: Zhang, Amy, et al.
Publicado: (2019)

The Biochemistry of Adenosylmethionine
por: Kraus, Jan
Publicado: (1978)

Characterization of the Candida albicans Amino Acid Permease Family: Gap2 Is the Only General Amino Acid Permease and Gap4 Is an S-Adenosylmethionine (SAM) Transporter Required for SAM-Induced Morphogenesis
por: Kraidlova, Lucie, et al.
Publicado: (2016)

Insights into the catalysis of a lysine-tryptophan bond in bacterial peptides by a SPASM domain radical S-adenosylmethionine (SAM) peptide cyclase
por: Benjdia, Alhosna, et al.
Publicado: (2017)

DIPG-20. Copper chelation therapy targets S-adenosylmethionine (SAM) metabolism and epigenetic regulators in diffuse intrinsic pontine glioma (DIPG)
por: Michniewicz, Filip, et al.
Publicado: (2022)

Hunting for Novel Routes in Anticancer Drug Discovery: Peptides against Sam-Sam Interactions
por: Mercurio, Flavia Anna, et al.
Publicado: (2022)

Enhancement of safety and immunogenicity of the Chinese Hu191 measles virus vaccine by alteration of the S-adenosylmethionine (SAM) binding site in the large polymerase protein
por: Wang, Yilong, et al.
Publicado: (2018)

Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer’s Model
por: Do Carmo, Sonia, et al.
Publicado: (2016)

Inflammation-Driven Reprogramming of CD4(+)Foxp3(+) Regulatory T Cells into Pathogenic Th1/Th17 T Effectors Is Abrogated by mTOR Inhibition in vivo
por: Yurchenko, Ekaterina, et al.
Publicado: (2012)

Radical S-Adenosylmethionine Enzymes
por: Broderick, Joan B., et al.
Publicado: (2014)

Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion
por: Dai, Meiou, et al.
Publicado: (2013)

Erratum to: Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion
por: Dai, Meiou, et al.
Publicado: (2017)

Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat
por: Dziegelewska, Maja, et al.
Publicado: (2016)

The Barley S-Adenosylmethionine Synthetase 3 Gene HvSAMS3 Positively Regulates the Tolerance to Combined Drought and Salinity Stress in Tibetan Wild Barley
por: Ahmed, Imrul Mosaddek, et al.
Publicado: (2020)

Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA
por: Joce, Catherine, et al.
Publicado: (2009)

Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer
por: Jung, Joon-Min, et al.
Publicado: (2023)

Natural history of S-adenosylmethionine-binding proteins
por: Kozbial, Piotr Z, et al.
Publicado: (2005)

Potential role of S-adenosylmethionine in osteosarcoma development
por: Shi, Hui, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ks658le1m1ei5gbmncf2m78uf6