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Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment

Tumor-mediated regulation of the host immune system involves an intricate signaling network that results in the tumor's inherent survival benefit. Myeloid cells are central in orchestrating the mechanisms by which tumors escape immune detection and continue their proliferative programming. Myel...

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Autores principales: Davidov, Vitaliy, Jensen, Garrett, Mai, Sunny, Chen, Shu-Hsia, Pan, Ping-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492293/
https://www.ncbi.nlm.nih.gov/pubmed/32983100
http://dx.doi.org/10.3389/fimmu.2020.01842
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author Davidov, Vitaliy
Jensen, Garrett
Mai, Sunny
Chen, Shu-Hsia
Pan, Ping-Ying
author_facet Davidov, Vitaliy
Jensen, Garrett
Mai, Sunny
Chen, Shu-Hsia
Pan, Ping-Ying
author_sort Davidov, Vitaliy
collection PubMed
description Tumor-mediated regulation of the host immune system involves an intricate signaling network that results in the tumor's inherent survival benefit. Myeloid cells are central in orchestrating the mechanisms by which tumors escape immune detection and continue their proliferative programming. Myeloid cell activation has historically been classified using a dichotomous system of classical (M1-like) and alternative (M2-like) states, defining general pro- and anti-inflammatory functions, respectively. Explosions in bioinformatics analyses have rapidly expanded the definitions of myeloid cell pro- and anti-inflammatory states with different combinations of tissue- and disease-specific phenotypic and functional markers. These new definitions have allowed researchers to target specific subsets of disease-propagating myeloid cells in order to modify or arrest the natural progression of the associated disease, especially in the context of tumor-immune interactions. Here, we discuss the myeloid cell contribution to solid tumor initiation and maintenance, and strategies to reprogram their phenotypic and functional fate, thereby disabling the network that benefits tumor survival.
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spelling pubmed-74922932020-09-25 Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment Davidov, Vitaliy Jensen, Garrett Mai, Sunny Chen, Shu-Hsia Pan, Ping-Ying Front Immunol Immunology Tumor-mediated regulation of the host immune system involves an intricate signaling network that results in the tumor's inherent survival benefit. Myeloid cells are central in orchestrating the mechanisms by which tumors escape immune detection and continue their proliferative programming. Myeloid cell activation has historically been classified using a dichotomous system of classical (M1-like) and alternative (M2-like) states, defining general pro- and anti-inflammatory functions, respectively. Explosions in bioinformatics analyses have rapidly expanded the definitions of myeloid cell pro- and anti-inflammatory states with different combinations of tissue- and disease-specific phenotypic and functional markers. These new definitions have allowed researchers to target specific subsets of disease-propagating myeloid cells in order to modify or arrest the natural progression of the associated disease, especially in the context of tumor-immune interactions. Here, we discuss the myeloid cell contribution to solid tumor initiation and maintenance, and strategies to reprogram their phenotypic and functional fate, thereby disabling the network that benefits tumor survival. Frontiers Media S.A. 2020-09-02 /pmc/articles/PMC7492293/ /pubmed/32983100 http://dx.doi.org/10.3389/fimmu.2020.01842 Text en Copyright © 2020 Davidov, Jensen, Mai, Chen and Pan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Davidov, Vitaliy
Jensen, Garrett
Mai, Sunny
Chen, Shu-Hsia
Pan, Ping-Ying
Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment
title Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment
title_full Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment
title_fullStr Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment
title_full_unstemmed Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment
title_short Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment
title_sort analyzing one cell at a time: analysis of myeloid cell contributions in the tumor immune microenvironment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492293/
https://www.ncbi.nlm.nih.gov/pubmed/32983100
http://dx.doi.org/10.3389/fimmu.2020.01842
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