Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy

Hypertriglyceridemia (HTG) is a common metabolic disorder with both genetic and lifestyle factors playing significant roles in its pathophysiology. HTG poses a risk for the development of cardiovascular disease (CVD) in the population at large and for pancreatitis in about two percent of individuals...

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Detalles Bibliográficos
Autores principales: Santos-Baez, Leinys S., Ginsberg, Henry N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492386/
https://www.ncbi.nlm.nih.gov/pubmed/32982991
http://dx.doi.org/10.3389/fendo.2020.00616
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author Santos-Baez, Leinys S.
Ginsberg, Henry N.
author_facet Santos-Baez, Leinys S.
Ginsberg, Henry N.
author_sort Santos-Baez, Leinys S.
collection PubMed
description Hypertriglyceridemia (HTG) is a common metabolic disorder with both genetic and lifestyle factors playing significant roles in its pathophysiology. HTG poses a risk for the development of cardiovascular disease (CVD) in the population at large and for pancreatitis in about two percent of individuals with extremely high levels of triglycerides (TG). This manuscript summarizes the mechanisms underlying the development of HTG as well as its management, including emerging therapies targeted at specific molecular pathways.
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spelling pubmed-74923862020-09-25 Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy Santos-Baez, Leinys S. Ginsberg, Henry N. Front Endocrinol (Lausanne) Endocrinology Hypertriglyceridemia (HTG) is a common metabolic disorder with both genetic and lifestyle factors playing significant roles in its pathophysiology. HTG poses a risk for the development of cardiovascular disease (CVD) in the population at large and for pancreatitis in about two percent of individuals with extremely high levels of triglycerides (TG). This manuscript summarizes the mechanisms underlying the development of HTG as well as its management, including emerging therapies targeted at specific molecular pathways. Frontiers Media S.A. 2020-09-02 /pmc/articles/PMC7492386/ /pubmed/32982991 http://dx.doi.org/10.3389/fendo.2020.00616 Text en Copyright © 2020 Santos-Baez and Ginsberg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Santos-Baez, Leinys S.
Ginsberg, Henry N.
Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy
title Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy
title_full Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy
title_fullStr Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy
title_full_unstemmed Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy
title_short Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy
title_sort hypertriglyceridemia—causes, significance, and approaches to therapy
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492386/
https://www.ncbi.nlm.nih.gov/pubmed/32982991
http://dx.doi.org/10.3389/fendo.2020.00616
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