Characterization and mitigation of gene expression burden in mammalian cells

Despite recent advances in circuit engineering, the design of genetic networks in mammalian cells is still painstakingly slow and fraught with inexplicable failures. Here, we demonstrate that transiently expressed genes in mammalian cells compete for limited transcriptional and translational resourc...

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Detalles Bibliográficos
Autores principales: Frei, Timothy, Cella, Federica, Tedeschi, Fabiana, Gutiérrez, Joaquín, Stan, Guy-Bart, Khammash, Mustafa, Siciliano, Velia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492461/
https://www.ncbi.nlm.nih.gov/pubmed/32934213
http://dx.doi.org/10.1038/s41467-020-18392-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492461/
https://www.ncbi.nlm.nih.gov/pubmed/32934213
http://dx.doi.org/10.1038/s41467-020-18392-x

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