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Characterization and mitigation of gene expression burden in mammalian cells
Despite recent advances in circuit engineering, the design of genetic networks in mammalian cells is still painstakingly slow and fraught with inexplicable failures. Here, we demonstrate that transiently expressed genes in mammalian cells compete for limited transcriptional and translational resourc...
Autores principales: | Frei, Timothy, Cella, Federica, Tedeschi, Fabiana, Gutiérrez, Joaquín, Stan, Guy-Bart, Khammash, Mustafa, Siciliano, Velia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492461/ https://www.ncbi.nlm.nih.gov/pubmed/32934213 http://dx.doi.org/10.1038/s41467-020-18392-x |
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