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Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study
BACKGROUND/AIMS: The evaluation of small bowel lesions of Crohn’s disease (CD) using balloon-assisted enteroscopy (BAE) is crucial because mucosal healing is associated with a good prognosis. However, BAE procedures are invasive, requiring sedation or analgesia to reduce the patient’s pain. This stu...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Office of Gut and Liver
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492490/ https://www.ncbi.nlm.nih.gov/pubmed/31818049 http://dx.doi.org/10.5009/gnl19228 |
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author | Takabayashi, Kaoru Hosoe, Naoki Kato, Motohiko Hayashi, Yukie Miyanaga, Ryoichi Nanki, Kosaku Fukuhara, Kayoko Mikami, Yohei Mizuno, Shinta Sujino, Tomohisa Mutaguchi, Makoto Naganuma, Makoto Yahagi, Naohisa Ogata, Haruhiko Kanai, Takanori |
author_facet | Takabayashi, Kaoru Hosoe, Naoki Kato, Motohiko Hayashi, Yukie Miyanaga, Ryoichi Nanki, Kosaku Fukuhara, Kayoko Mikami, Yohei Mizuno, Shinta Sujino, Tomohisa Mutaguchi, Makoto Naganuma, Makoto Yahagi, Naohisa Ogata, Haruhiko Kanai, Takanori |
author_sort | Takabayashi, Kaoru |
collection | PubMed |
description | BACKGROUND/AIMS: The evaluation of small bowel lesions of Crohn’s disease (CD) using balloon-assisted enteroscopy (BAE) is crucial because mucosal healing is associated with a good prognosis. However, BAE procedures are invasive, requiring sedation or analgesia to reduce the patient’s pain. This study evaluated the clinical usefulness of a novel ultrathin single-balloon enteroscopy (SBE) procedure for CD. METHODS: This single-center retrospective study included 102 CD patients who underwent trans-anal SBE between January 2012 and May 2018. Of these patients, 82 underwent enteroscopy using conventional SBE, while 20 underwent ultrathin SBE. Patients were analyzed using propensity score matching, with 20 patients per group. The median duration of the examination, terminal ileum intubation rate, median cecum intubation time, median insertion depth, adverse events, and sedated dose in each group were compared. RESULTS: Before propensity score matching, the conventional SBE group had a larger number of surgical history patients than the ultrathin SBE group (p=0.05). After matching, the two groups did not significantly differ clinically. There were no significant differences in the mean duration of the examination, cecum intubation time, or terminal ileal intubation rate between ultrathin SBE and conventional SBE. The mean insertion depth of ultrathin SBE tended to be deeper than that of conventional SBE (p=0.09). The use of ultrathin SBE also reduced the sedative dose during needed for enteroscopy compared with conventional SBE (p=0.005). CONCLUSIONS: Novel ultrathin SBE may be less painful for CD patients than conventional SBE. |
format | Online Article Text |
id | pubmed-7492490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Editorial Office of Gut and Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-74924902020-09-22 Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study Takabayashi, Kaoru Hosoe, Naoki Kato, Motohiko Hayashi, Yukie Miyanaga, Ryoichi Nanki, Kosaku Fukuhara, Kayoko Mikami, Yohei Mizuno, Shinta Sujino, Tomohisa Mutaguchi, Makoto Naganuma, Makoto Yahagi, Naohisa Ogata, Haruhiko Kanai, Takanori Gut Liver Original Article BACKGROUND/AIMS: The evaluation of small bowel lesions of Crohn’s disease (CD) using balloon-assisted enteroscopy (BAE) is crucial because mucosal healing is associated with a good prognosis. However, BAE procedures are invasive, requiring sedation or analgesia to reduce the patient’s pain. This study evaluated the clinical usefulness of a novel ultrathin single-balloon enteroscopy (SBE) procedure for CD. METHODS: This single-center retrospective study included 102 CD patients who underwent trans-anal SBE between January 2012 and May 2018. Of these patients, 82 underwent enteroscopy using conventional SBE, while 20 underwent ultrathin SBE. Patients were analyzed using propensity score matching, with 20 patients per group. The median duration of the examination, terminal ileum intubation rate, median cecum intubation time, median insertion depth, adverse events, and sedated dose in each group were compared. RESULTS: Before propensity score matching, the conventional SBE group had a larger number of surgical history patients than the ultrathin SBE group (p=0.05). After matching, the two groups did not significantly differ clinically. There were no significant differences in the mean duration of the examination, cecum intubation time, or terminal ileal intubation rate between ultrathin SBE and conventional SBE. The mean insertion depth of ultrathin SBE tended to be deeper than that of conventional SBE (p=0.09). The use of ultrathin SBE also reduced the sedative dose during needed for enteroscopy compared with conventional SBE (p=0.005). CONCLUSIONS: Novel ultrathin SBE may be less painful for CD patients than conventional SBE. Editorial Office of Gut and Liver 2020-09-15 2019-12-12 /pmc/articles/PMC7492490/ /pubmed/31818049 http://dx.doi.org/10.5009/gnl19228 Text en Copyright © 2020 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Takabayashi, Kaoru Hosoe, Naoki Kato, Motohiko Hayashi, Yukie Miyanaga, Ryoichi Nanki, Kosaku Fukuhara, Kayoko Mikami, Yohei Mizuno, Shinta Sujino, Tomohisa Mutaguchi, Makoto Naganuma, Makoto Yahagi, Naohisa Ogata, Haruhiko Kanai, Takanori Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study |
title | Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study |
title_full | Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study |
title_fullStr | Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study |
title_full_unstemmed | Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study |
title_short | Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study |
title_sort | efficacy of novel ultrathin single-balloon enteroscopy for crohn’s disease: a propensity score-matched study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492490/ https://www.ncbi.nlm.nih.gov/pubmed/31818049 http://dx.doi.org/10.5009/gnl19228 |
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