Cargando…
Pemphigus Oral Lesions Intensity Score (POLIS): A Novel Scoring System for Assessment of Severity of Oral Lesions in Pemphigus Vulgaris
Background: Many patients with pemphigus vulgaris (PV) in India present with predominant/exclusive oral mucosal lesions. Current validated scoring systems for pemphigus do not adequately represent the clinical variability of oral lesions. Objective: To develop and validate a novel scoring system exc...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492520/ https://www.ncbi.nlm.nih.gov/pubmed/32984362 http://dx.doi.org/10.3389/fmed.2020.00449 |
_version_ | 1783582382548320256 |
---|---|
author | Sindhuja, Tekumalla De, Dipankar Handa, Sanjeev Goel, Sonu Mahajan, Rahul Kishore, Kamal |
author_facet | Sindhuja, Tekumalla De, Dipankar Handa, Sanjeev Goel, Sonu Mahajan, Rahul Kishore, Kamal |
author_sort | Sindhuja, Tekumalla |
collection | PubMed |
description | Background: Many patients with pemphigus vulgaris (PV) in India present with predominant/exclusive oral mucosal lesions. Current validated scoring systems for pemphigus do not adequately represent the clinical variability of oral lesions. Objective: To develop and validate a novel scoring system exclusively for oral lesions in PV. Methods: In this cross-sectional study, the Delphi method was used to build an initial scale that was administered in 115 patients with PV. Exploratory factor analysis was used to examine the underlying factor structure of the new scale. The psychometric properties of the new scale were studied. Correlations between the new scale and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS), Pemphigus Disease Area Index (PDAI), and Physician Global Assessment (PGA) were also assessed. Results: Content validity of the initial scale was established with an average content validity index (CVI) of 0.8. Exploratory factor analysis resulted in a 3-factor structure with a total of 9 items. Corrected item-total correlation, a measure of data quality, was more than 0.30 for all items in the new oral mucosal scale—Pemphigus Oral Lesions Intensity Score (POLIS). Significant correlations were observed between POLIS and oral ABSIS (r = 0.85, p < 0.001), mucosal PDAI (r = 0.70, p < 0.001), and PGA (r = 0.60, p < 0.001). POLIS was also reliable with good internal consistency (Cronbach's α = 0.86) and strong inter-rater agreement. Limitations: The study cohort included participants from a single center. Usability and time taken to administer the scale were not assessed. Conclusions: The new scale, POLIS, has adequate validity and reliability. It includes both quality of life and clinical disease severity parameters, assessing disease severity holistically. Further studies evaluating the scale's responsiveness to change are in progress. |
format | Online Article Text |
id | pubmed-7492520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74925202020-09-25 Pemphigus Oral Lesions Intensity Score (POLIS): A Novel Scoring System for Assessment of Severity of Oral Lesions in Pemphigus Vulgaris Sindhuja, Tekumalla De, Dipankar Handa, Sanjeev Goel, Sonu Mahajan, Rahul Kishore, Kamal Front Med (Lausanne) Medicine Background: Many patients with pemphigus vulgaris (PV) in India present with predominant/exclusive oral mucosal lesions. Current validated scoring systems for pemphigus do not adequately represent the clinical variability of oral lesions. Objective: To develop and validate a novel scoring system exclusively for oral lesions in PV. Methods: In this cross-sectional study, the Delphi method was used to build an initial scale that was administered in 115 patients with PV. Exploratory factor analysis was used to examine the underlying factor structure of the new scale. The psychometric properties of the new scale were studied. Correlations between the new scale and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS), Pemphigus Disease Area Index (PDAI), and Physician Global Assessment (PGA) were also assessed. Results: Content validity of the initial scale was established with an average content validity index (CVI) of 0.8. Exploratory factor analysis resulted in a 3-factor structure with a total of 9 items. Corrected item-total correlation, a measure of data quality, was more than 0.30 for all items in the new oral mucosal scale—Pemphigus Oral Lesions Intensity Score (POLIS). Significant correlations were observed between POLIS and oral ABSIS (r = 0.85, p < 0.001), mucosal PDAI (r = 0.70, p < 0.001), and PGA (r = 0.60, p < 0.001). POLIS was also reliable with good internal consistency (Cronbach's α = 0.86) and strong inter-rater agreement. Limitations: The study cohort included participants from a single center. Usability and time taken to administer the scale were not assessed. Conclusions: The new scale, POLIS, has adequate validity and reliability. It includes both quality of life and clinical disease severity parameters, assessing disease severity holistically. Further studies evaluating the scale's responsiveness to change are in progress. Frontiers Media S.A. 2020-09-02 /pmc/articles/PMC7492520/ /pubmed/32984362 http://dx.doi.org/10.3389/fmed.2020.00449 Text en Copyright © 2020 Sindhuja, De, Handa, Goel, Mahajan and Kishore. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Sindhuja, Tekumalla De, Dipankar Handa, Sanjeev Goel, Sonu Mahajan, Rahul Kishore, Kamal Pemphigus Oral Lesions Intensity Score (POLIS): A Novel Scoring System for Assessment of Severity of Oral Lesions in Pemphigus Vulgaris |
title | Pemphigus Oral Lesions Intensity Score (POLIS): A Novel Scoring System for Assessment of Severity of Oral Lesions in Pemphigus Vulgaris |
title_full | Pemphigus Oral Lesions Intensity Score (POLIS): A Novel Scoring System for Assessment of Severity of Oral Lesions in Pemphigus Vulgaris |
title_fullStr | Pemphigus Oral Lesions Intensity Score (POLIS): A Novel Scoring System for Assessment of Severity of Oral Lesions in Pemphigus Vulgaris |
title_full_unstemmed | Pemphigus Oral Lesions Intensity Score (POLIS): A Novel Scoring System for Assessment of Severity of Oral Lesions in Pemphigus Vulgaris |
title_short | Pemphigus Oral Lesions Intensity Score (POLIS): A Novel Scoring System for Assessment of Severity of Oral Lesions in Pemphigus Vulgaris |
title_sort | pemphigus oral lesions intensity score (polis): a novel scoring system for assessment of severity of oral lesions in pemphigus vulgaris |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492520/ https://www.ncbi.nlm.nih.gov/pubmed/32984362 http://dx.doi.org/10.3389/fmed.2020.00449 |
work_keys_str_mv | AT sindhujatekumalla pemphigusorallesionsintensityscorepolisanovelscoringsystemforassessmentofseverityoforallesionsinpemphigusvulgaris AT dedipankar pemphigusorallesionsintensityscorepolisanovelscoringsystemforassessmentofseverityoforallesionsinpemphigusvulgaris AT handasanjeev pemphigusorallesionsintensityscorepolisanovelscoringsystemforassessmentofseverityoforallesionsinpemphigusvulgaris AT goelsonu pemphigusorallesionsintensityscorepolisanovelscoringsystemforassessmentofseverityoforallesionsinpemphigusvulgaris AT mahajanrahul pemphigusorallesionsintensityscorepolisanovelscoringsystemforassessmentofseverityoforallesionsinpemphigusvulgaris AT kishorekamal pemphigusorallesionsintensityscorepolisanovelscoringsystemforassessmentofseverityoforallesionsinpemphigusvulgaris |