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Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life...

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Autores principales: Feng, Min, Fei, Shigang, Xia, Junming, Labropoulou, Vassiliki, Swevers, Luc, Sun, Jingchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492552/
https://www.ncbi.nlm.nih.gov/pubmed/32983149
http://dx.doi.org/10.3389/fimmu.2020.02030
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author Feng, Min
Fei, Shigang
Xia, Junming
Labropoulou, Vassiliki
Swevers, Luc
Sun, Jingchen
author_facet Feng, Min
Fei, Shigang
Xia, Junming
Labropoulou, Vassiliki
Swevers, Luc
Sun, Jingchen
author_sort Feng, Min
collection PubMed
description Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs.
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spelling pubmed-74925522020-09-25 Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response Feng, Min Fei, Shigang Xia, Junming Labropoulou, Vassiliki Swevers, Luc Sun, Jingchen Front Immunol Immunology Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs. Frontiers Media S.A. 2020-09-02 /pmc/articles/PMC7492552/ /pubmed/32983149 http://dx.doi.org/10.3389/fimmu.2020.02030 Text en Copyright © 2020 Feng, Fei, Xia, Labropoulou, Swevers and Sun. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Feng, Min
Fei, Shigang
Xia, Junming
Labropoulou, Vassiliki
Swevers, Luc
Sun, Jingchen
Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response
title Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response
title_full Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response
title_fullStr Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response
title_full_unstemmed Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response
title_short Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response
title_sort antimicrobial peptides as potential antiviral factors in insect antiviral immune response
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492552/
https://www.ncbi.nlm.nih.gov/pubmed/32983149
http://dx.doi.org/10.3389/fimmu.2020.02030
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